115131-71-0Relevant articles and documents
Orally Potent Human Renin Inhibitors Derived from Angiotensinogen Transition State: Design, Synthesis, and Mode of Interaction
Iizuka, Kinji,Kamijo, Tetsuhide,Herada, Hiromu,Akahane, Kenji,Kubota, Tetsuhiro,et al.
, p. 2707 - 2714 (2007/10/02)
A three-dimensional structure of the complex of human renin and the scissile site P4 Pro to P1' Val of angiotensinogen was deduced in order to design potent human renin inhibitors rationally.On the basis of this structure, an orally
A Practical Synthesis of an Orally Potent Renin Inhibitor, Isopropyl (2R,3S)-4-Cyclohexyl-2-hydroxy-3--L-histidyl>aminobutyrate
Harada, Hiromu,Iyobe, Akira,Tsubaki, Atsushi,Yamaguchi, Toshiaki,Hirata, Kazuma,et al.
, p. 2497 - 2500 (2007/10/02)
The practical synthesis of an orally potent human renin inhibitor, isopropyl (2R,3S)-4-cyclohexyl-2-hydroxy-3--L-histidyl>aminobutyrate, is presented.Optically pure cyclohexylnorstatine isopropyl
MORPHOLINE CONTAINING AMINO ACID DERIVATIVES
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, (2008/06/13)
Amino acid derivatives represented by formula STR1 wherein His represents an L-histidyl group, X represents a straight or branched alkoxy group having 1 to 7 carbon atoms, a straight or branched alkylamino group having 1 to 7 carbon atoms, a cycloalkyloxy