121506-22-7

Upstream product

• 74-90-8 hydrogen cyanide 
• 98105-42-1 (S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal 
• 128540-53-4 (S)-3-cyclohexyl-2-(isopropoxycarbonyl)aminopropanol 
• 143-33-9 sodium cyanide 
• 126832-06-2 N-benzoylcyclohexylalaninal 
• 139056-99-8 (2R,3S)-3-Benzylamino-4-cyclohexyl-2-hydroxybutyric acid hydrochloride 
• 126832-07-3 (2R,3S)-3-benzoylamino-4-cyclohexyl-2-hydroxybutyronitrile 
• 117499-04-4 -1-(cyclohexylmethyl)-2-cyano-2-hydroxycarbamic acid, 1,1-dimethylethyl ester 
• 130115-06-9 (R)-methyl 2-tert-butoxy-2-phenylacetate 
• 130115-19-4 Benzyl-[(R)-2-tert-butoxy-2-phenyl-eth-(E)-ylidene]-amine 
• 130115-17-2 Benzyl-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-eth-(E)-ylidene]-amine 
• 130115-13-8 (4R,5R)-1-benzyl-5-<(R)-(1-benzyloxy-1-isopropoxycarbonyl)methyl>-4-phenyl-2-oxazolidone 
• 130115-07-0 (R)-2-(t-butyldimethylsilyloxy)-2-phenylacetaldehyde 
• 119660-39-8 isopropyl (2R,3S)-3-amino-2-hydroxy-4-phenylbutyrate 

Downstream Products

• 105116-44-7 N-Boc-cyclohexylnorstatin 
• 115131-71-0 2(R)-Hydroxy-3(S)-amino-4-cyclohexylbutanoic acid, 2-propanol ester, hydrochloride 
• 167823-29-2 4-cyclohexyl-3-(S)-ethoxycarbonylamino-2-(R)-hydroxybutyric acid 
• 122621-77-6 (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 156540-64-6 ((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-carbamic acid ethyl ester 
• 167823-30-5 ((1S,2R)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-3-oxo-hexyl)-carbamic acid ethyl ester 
• 128053-53-2 KRI-1314 
• 126832-09-5 (4S,5R)-4-cyclohexylmethyl-2-oxazolidinone-5-carboxylic acid isopropyl ester 
• 140462-45-9 methyl (2R,3S)-2-acetoxy-3-acetylamino-4-cyclohexylbutyrate 
• 115131-72-1 isopropyl (2S,3S)-3-amino-4-cyclohexyl-2-hydroxybutyrate hydrochloride 
• 128053-57-6 isopropyl (2S,3S)-3-<-L-histidyl>amino>-4-cyclohexyl-2-hydroxybutyrate 
• 276888-52-9 (2RS,3S)-3-tert-butyloxycarbonylamino-4-cyclohexyl-2-hydroxybutyric acid 
• 129704-26-3 isopropyl (2R,3R)-3-amino-4-cyclohexyl-2-hydroxybutyrate hydrochloride 
• 128053-56-5 isopropyl (2R,3R)-3-<-L-histidyl>amino>-4-cyclohexyl-2-hydroxybutyrate 

Relevant academic research and scientific papers

Practical preparation of α-hydroxy-β-amino ester units; Stereoselective synthesis of taxol side chain and norstatine

An asymmetric reaction of chiral imines with α-silyloxy ketene acetals mediated by chiral boron reagents is described. The key to its success is the use of the chiral boron complex prepared in situ from (R)- or (S)-binaphthol and B(OPh)3. Both diastereomers of α-hydroxy-β-amino ester units are successfully prepared with high selectivities by the chiral boron reagents depending on the geometry of the silyl ketene acetals. The optically pure anti α-hydroxy-β-amino ester is obtained from (E)-silyl ketene acetal, while the corresponding syn α-hydroxy-β-amino ester is obtained from (Z)- silyl ketene acetal. The method can be efficiently applied to the stereoselective synthesis of taxol C-13 side chain and the norstatine family.

Stereocontrolled asymmetric synthesis of α-hydroxy-β-amino acids. A stereodivergent approach

The stereocontrolled asymmetric synthesis of α-hydroxy-β-amino acids has been investigated via the Lewis acid-promoted cyanation of (5R,6S)-2-acetoxy-4-(benzyloxycarbonyl)-5, 6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazines with trimethylsilyl cyanide. Base-

Process for the production of chiral hydroxy-β-lactams and hydroxyamino acids derived therefrom

The reaction between a hydroxyacetic acid derivative bearing an oxygen protecting group and a chiral auxiliary group and an imine produces chiral β-lactams. Hydrolysis of the chiral β-lactams produces chiral amino acid analogs.

A Practical Synthesis of threo-3-Amino-2-hydroxycarboxylic Acids

An expeditious synthesis of (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid (2) and (2S,3R)-3-amino-2-hydroxy-4-phenylbutyric acid (4), the key components of the renin inhibitor (1) and bestatin (3), respectively, have been accomplished by featuring hi

New and efficient routes to norstatine and its analogs with high enantiomeric purity by β-Lactam Synthon Method

Norstatine and its analogs, i.e., 3-amino-2-hydroxyalkanoic acids, with high enantiomeric purity are obtained through effecient asymmetric synthesis of 3-silyloxy-β-lactams by chiral enolate - imine cyclocondensation, followed by hydrolysis.

A Stereoselective Synthesis of the (2R,3S)- and (2S,3R)-3-Amino-2-hydroxybutyric Acid Derivatives, the Key Components of a Renin Inhibitor and Bestatin

The title synthesis was achieved by featuring the -cycloaddition reaction of benzyloxyketene with a chiral imine derived from methyl (R)- or (S)-mandelate, alcoholysis of the formed 3,4-cis disubstituted β-lactam under acidic conditions, and reductiv

Novel synthesis of three types of C-terminal components of renin inhibitors from unnatural (2S,3S)-tartaric acid

The addition reaction of cyclohexylmethylmagnesium bromide with the imine prepared from unnatural (2S,3S)-tartaric acid was found to proceed in a highly stereoselective manner in the presence of cerium(III) chloride. A chelation-controlled mechanism could

A stereoselective synthesis of cyclohexylnorstatine, the key component of a renin inhibitor

The title synthesis could be accomplished by employing the novel addition reaction of a Grignard reagent with an imine in the presence of cerium(III) chloride.

An Expeditions Synthesis of the (2R,3S)- and (2S,3R)-3-Amino-2-hydroxy-carboxylic Acids, the Key Components of a Renin Inhibitor and Bestatin, from (S)- and (R)-Phenylalanine

The title synthesis could be achieved by featuring highly diastereoselective formation of a cyanohydrin acetate from an aldehyde under the phase-transfer conditions.