1151802-23-1

Basic information

• Product Name: 4-bromo-1-cyclopropyl-1H-pyrazole
• Synonyms: 4-bromo-1-cyclopropyl-1H-pyrazole;4-bromo-1-cyclopropylpyrazole
• CAS NO: 1151802-23-1
• Molecular Formula: C₆H₇BrN₂
• Molecular Weight: 187.03718
• Mol File: 1151802-23-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 258.6±13.0 °C(Predicted)
• Appearance: /
• Density: 1.87±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.36±0.12(Predicted)
• CAS DataBase Reference: 4-bromo-1-cyclopropyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-1-cyclopropyl-1H-pyrazole(1151802-23-1)
• EPA Substance Registry System: 4-bromo-1-cyclopropyl-1H-pyrazole(1151802-23-1)

Safety Data

• Hazardous Substances Data: 1151802-23-1(Hazardous Substances Data)

Usage

Uses

4-Bromo-1-cyclopropyl-1H-pyrazole is used in the treatment of cancer as a triazolopyridazine c-Met kinase inhibitor.

Upstream product

• 2075-45-8 4-bromo-1H-pyrazole 
• 411235-57-9 cyclopropylboronic acid 
• 4333-56-6 cyclopropyl bromide 
• 1151814-36-6 1-cyclopropylpyrazole 

Downstream Products

• 1151802-22-0 1-cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 
• 1440965-10-5 3-chloro-6-(1-cyclopropyl-1H-pyrazol-4-yl)pyridazine 

Relevant articles and documents

DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF

The present invention relates to a group of 1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one (piperlongumine) derivatives, analogs and pharmaceutically acceptable salts thereof. The present invention also relates to a pharmaceutical composition and formulation containing a derivative of piperlongumine; and use of the derivatives and analogs for treating cancer, reducing inflammation and/or treating an autoimmune or inflammatory disease.

PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES

Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.