1440965-10-5

Upstream product

• 1151802-23-1 4-bromo-1-cyclopropyl-1H-pyrazole 
• 141-30-0 3,6-dichlorpyridazine 
• 1151802-22-0 1-cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 
• 1374652-23-9 cyclopropylhydrazine dihydrochloride 
• 1121-79-5 3-chloro-6-methylpyridazine 

Relevant academic research and scientific papers

Preparation method and intermediate of pyrazole compound

The invention discloses a preparation method and an intermediate of a pyrazole compound. The invention specifically discloses a preparation method of a compound B. The preparation method provided by the invention has one or more advantages as follows: the operation is simple, the yield is relatively high, the cost is low, and the method is suitable for industrial production.

HIGHLY SELECTIVE C-MET INHIBITORS AS ANTICANCER AGENTS

Disclosed are novel nitrogen-containing, heterocyclic, c-Met inhibitor compounds, processes for their preparation and formulations thereof. The compounds are useful as therapeutical agents for the inhibition, regulation, and control of c-Met kinase signal pathway, and useful for treating in a subject a cell proliferative disorder or disorders mediated by c-Met.