1151930-57-2Relevant articles and documents
Discovery of non-peptidergic MrgX1 and MrgX2 receptor agonists and exploration of an initial SAR using solid-phase synthesis
Malik, Leila,Kelly, Nicholas M.,Ma, Jian-Nong,Currier, Erika A.,Burstein, Ethan S.,Olsson, Roger
scheme or table, p. 1729 - 1732 (2010/02/28)
A class of small molecules displaying comparable activities with peptide ligands BAM22 and corticostatin-14 at both the human and rhesus monkey MrgX1 and MrgX2 receptors, respectively, was discovered. A comparative study to compare solid-phase and solution-phase chemistries for the efficient synthesis of the active class, tetracyclic benzimidazoles, was undertaken. The solid-phase chemistry was found to be superior both for the synthesis of analogs and for the synthesis of gram quantities.
