115198-80-6

Basic information

• Product Name: TERT-BUTYL N-(2-OXIRANYLMETHYL)CARBAMATE
• Synonyms: Carbamic acid, (oxiranylmethyl)-, 1,1-dimethylethyl ester (9CI);tert-Butyl N-(2-oxiranylMethyl)carbaMate 97%
• CAS NO: 115198-80-6
• Molecular Formula: C₈H₁₅NO₃
• Molecular Weight: 173.2096
• Product Categories: N-BOC;API intermediates;Epoxides;Organic Building Blocks;Oxygen Compounds
• Mol File: 115198-80-6.mol
• Article Data: 18

Chemical Properties

• Melting Point: 48 °C
• Boiling Point: 262.908°C at 760 mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.041 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.011mmHg at 25°C
• Refractive Index: n20/D 1.4500(lit.)
• PKA: 12.45±0.46(Predicted)
• CAS DataBase Reference: TERT-BUTYL N-(2-OXIRANYLMETHYL)CARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL N-(2-OXIRANYLMETHYL)CARBAMATE(115198-80-6)
• EPA Substance Registry System: TERT-BUTYL N-(2-OXIRANYLMETHYL)CARBAMATE(115198-80-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 115198-80-6(Hazardous Substances Data)

Usage

General Description

TERT-BUTYL N-(2-OXIRANYLMETHYL)CARBAMATE is a chemical compound with the molecular formula C8H15NO4. It is commonly used as a reagent in organic synthesis, particularly in the formation of carbamate and urea derivatives. TERT-BUTYL N-(2-OXIRANYLMETHYL)CARBAMATE is insoluble in water but can dissolve in organic solvents such as ethanol and acetone. TERT-BUTYL N-(2-OXIRANYLMETHYL)CARBAMATE is known to have low acute toxicity, but prolonged exposure or inhalation may cause irritation to the respiratory system. It is important to handle this chemical with caution and use proper protective equipment when working with it in a laboratory setting.

InChI:InChI=1/C8H15NO3/c1-8(2,3)12-7(10)9-4-6-5-11-6/h6H,4-5H2,1-3H3,(H,9,10)

Upstream product

• 34619-03-9 tert-butyldicarbonate 
• 570390-94-2 tert-butyl-3-chloro-2-hydroxypropylcarbamate 
• 137618-48-5 tert-butyl N-(2,3-dihydroxypropyl)carbamate 
• 78888-18-3 N-tert-butoxycarbonylprop-2-en-1-amine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 144912-84-5 (3-amino-2-hydroxypropyl)carbamic acid 1,1-dimethylethyl ester 
• 162541-45-9 (RS)-2-<(tert-Butoxycarbonyl)amino>-1-benzylethanol 
• 1283093-89-9 C₁₀₈H₁₆₄N₆O₂₇Si₅ 
• 1150307-23-5 5-[Acetyl-(3-amino-2-hydroxy-propyl)-amino]-N,N'-bis-(2,3-dihydroxy-propyl)-2,4,6-triiodo-isophthalamide 
• 149057-20-5 (R)-<<(tert-butoxycarbonyl)amino>methyl>oxirane 
• 161513-47-9 (S)-<<(tert-butoxycarbonyl)amino>methyl>oxirane 

Relevant articles and documents

Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif

Trypanosoma brucei, the parasite that causes human African trypanosomiasis, is auxotrophic for purines and has specialist nucleoside transporters to import these metabolites. In particular, the P2 aminopurine transporter can also selectively accumulate melamine derivatives. In this Letter, we report the coupling of the melamine moiety to 2-hydroxy APA, a potent ornithine decarboxylase inhibitor, with the aim of selectively delivering this compound to the parasite. The best compound described here shows an increased in vitro trypanocidal activity compared with the parent.

BISPHOSPHONATE-LINKED COMPOUNDS

The present invention concerns novel compounds useful in the treatment of cancer, particularly including compounds linking a bisphosphonate moiety with KBU2046, and pharmaceutically acceptable salts, co-crystals, polymorphs, solvates, hydrates, and enantiomers thereof, as well as methods for their production and pharmaceutical compositions comprising them.

TGR5 AGONISTS

The invention relates to novel 1,4-diazepan-2-one compounds, which are TGR5 agonists and useful for the treatment of metabolic disorders, inflammatory diseases, atherosclerosis and dyslipidemias.