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5-(N-tert-butyl)amiloride, also known as T-amiloride or 5-N-(tert-butyl)amiloride, is a chemical compound with the molecular formula C10H21N3O. It is a derivative of amiloride, a potassium-sparing diuretic, and is used as a pharmacological tool to inhibit the epithelial sodium channel (ENaC) in various cell types, including those in the kidney, lung, and colon. This inhibition helps in studying the role of ENaC in sodium transport and its impact on fluid balance and blood pressure regulation. T-amiloride is a potent and selective blocker of ENaC, making it a valuable research tool in the field of ion channel biology and related therapeutic applications.

1152-29-0

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1152-29-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1152-29-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,5 and 2 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1152-29:
(6*1)+(5*1)+(4*5)+(3*2)+(2*2)+(1*9)=50
50 % 10 = 0
So 1152-29-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H16ClN7O/c1-10(2,3)18-7-5(11)15-4(6(12)16-7)8(19)17-9(13)14/h1-3H3,(H3,12,16,18)(H4,13,14,17,19)

1152-29-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-amino-5-(tert-butylamino)-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide

1.2 Other means of identification

Product number -
Other names 3-amino-5-tert-butylamino-6-chloro-pyrazine-2-carboxylic acid carbamimidoylamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1152-29-0 SDS

1152-29-0Downstream Products

1152-29-0Relevant academic research and scientific papers

Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3)

Kuduk, Scott D.,Di Marco, Christina N.,Chang, Ronald K.,DiPardo, Robert M.,Cook, Sean P.,Cato, Matthew J.,Jovanovska, Aneta,Urban, Mark O.,Leitl, Michael,Spencer, Robert H.,Kane, Stefanie A.,Bilodeau, Mark T.,Hartman, George D.,Bock, Mark G.

scheme or table, p. 2514 - 2518 (2009/12/25)

A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain.

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