1152617-02-1Relevant articles and documents
Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor
Tresadern, Gary,Cid, Jose Maria,Macdonald, Gregor J.,Vega, Juan Antonio,de Lucas, Ana Isabel,Garcia, Aranzazu,Matesanz, Encarnacion,Linares, Maria Lourdes,Oehlrich, Daniel,Lavreysen, Hilde,Biesmans, Ilse,Trabanco, Andres A.
, p. 175 - 179 (2010)
Imidazo[1,2-a]pyridines were identified via their shape and electrostatic similarity as novel positive allosteric modulators of the metabotropic glutamate 2 receptor. The subsequent synthesis and SAR are described. Potent, selective and metabolically stable compounds were found representing a promising avenue for current further studies.