115263-24-6Relevant academic research and scientific papers
Gold-catalyzed benzylation of arenes and heteroarenes
Mertins, Kristin,Iovel, Irina,Kischel, Jette,Zapf, Alexander,Beller, Matthias
, p. 691 - 695 (2006)
Friedel-Crafts type benzylation of arenes and heteroarenes with benzylic acetates, alcohols, and carbonates is effectively promoted under mild reaction conditions using catalytic amounts of gold salts. The resulting 1,1-diarylalkanes and 1-aryl-1-heteroarylalkanes are obtained in high yields and with high selectivity. The utility of the method is demonstrated by a short synthesis of beclobrate {ethyl 2-[4-(4-chlorobenzyl)-phenoxy]-2-methylbutyrate (3)}, a fibric acid derivative.
Transition-metal-catalyzed benzylation of arenes and heteroarenes
Mertins, Kristin,Iovel, Irina,Kischel, Jette,Zapf, Alexander,Beller, Matthias
, p. 238 - 242 (2007/10/03)
Friedel-Crafts-type benzylation of various aromatic and heteroaromatic compounds with benzylic acetates, alcohols, and carbonates was promoted under mild reaction conditions by a series of Rh, Ir, Pd, and Pt catalysts (see scheme; R1 = H, Me; R2 = H, Cl, MeO; R3 = H, Ac, CO2Me). The desired products were obtained in high yields and with high selectivities.
An efficient and general iron-catalyzed arylation of benzyl alcohols and benzyl carboxylates
Iovel, Irina,Mertins, Kristin,Kischel, Jette,Zapf, Alexander,Beller, Matthias
, p. 3913 - 3917 (2007/10/03)
(Chemical Equation Presented) Green grow the diarylmethanes: Substituted arenes and heteroarenes can be easily benzylated in the presence of inexpensive and relatively nontoxic metal salts such as FeCl3 (see scheme). This arylation method with benzyl alcohols is a state-of-the-art green route to diarylmethanes as water is the only by-product.
REACTION OF DISUBSTITUTED AROMATIC COMPOUNDS WITH STYRENE
Grushin, A. I.,Grigor'ev, V. V.,Prokof'ev, K. V.,Kozlova, N. M.
, p. 1939 - 1941 (2007/10/02)
Hydrocarbons of the 1,1-diphenylethane typr vere obtained by the reaction of styrene with various disubstituted derivatives of benzene in the presence of titanium tetrachloride.It was found that the yield of the desired compound depends on the strength of the electron-donating substituents and on steric factors in the aromatic ring.
