115269-11-9

Upstream product

• 108-24-7 acetic anhydride 
• 115236-89-0 3-O-acetyl-5-O-benzoyl-1,2-O-isopropylidene-α-D-ribofuranose 
• 5517-60-2 methyl 3'-O-benzoyl-2,3-O-isopropylidene-β-D-apiofuranoside 
• 4099-85-8 ((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol 
• 36468-53-8 β-D-ribofuranose 

Downstream Products

• 2346620-55-9 molnupiravir acetonide 
• 362-42-5 2',3'-O-isopropylidenecytidine 
• 65-46-3 CYTIDINE 
• 120090-41-7 methyl 2-O-acetyl-5-O-benzoyl-3-O-(2,3-di-O-acetyl-5-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranoside 
• 120090-40-6 methyl 3-O-acetyl-5-O-benzoyl-2-O-(2,3-di-O-acetyl-5-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranoside 
• 120090-38-2 methyl 2,3-di-O-acetyl-5-O-(2,3-di-O-acetyl-5-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranoside 

Relevant academic research and scientific papers

Conversion of: N- acyl amidines to amidoximes: A convenient synthetic approach to molnupiravir (EIDD-2801) from ribose

An efficient method is described for the preparation of molnupiravir (EIDD-2801) an antiviral agent via regioselective conversion of an N-acyl-nucleoside intermediate, generated through stereo and regioselective glycosylation of protected ribose and N4-acetyl cytosine, to an amidoxime. This method avoids use of expensive starting materials, enzymes, complex reagents, and cumbersome purification procedures.

EPIMERIZATION DURING THE ACETOLYSIS OF 3-O-ACETYL-5-O-BENZOYL-1,2-O-ISOPROPYLIDENE-3-C-METHYL-α-D-RIBOFURANOSE. SYNTHESIS OF 3'-C-METHYLNUCLEOSIDES WITH THE β-D-ribo- AND α-D-arabino CONFIGURATIONS

Acetolysis of 3-O-acetyl-5-O-benzoyl-1,2-O-isopropylidene-3-C-methyl-α-D-ribofuranose with a high concentration of acetic acid yielded 1,2,3-tri-O-acetyl-5-O-benzoyl-3-C-methyl-D-arabinofuranose, which was used for the preparation of 3-C-methyl-α-D-arabinofuranosyl nucleosides. 3'-C-Methylribonucleosides were also synthesized starting from 1,2,3-tri-O-acetyl-5-O-benzoyl-3-C-C-methyl-D-ribofuranose.