115270-35-4Relevant academic research and scientific papers
COtab: Expedient and Safe Setup for Pd-Catalyzed Carbonylation Chemistry
Collin, Hugo P.,Reis, Wallace J.,Nielsen, Dennis U.,Lindhardt, Anders T.,Valle, Marcelo S.,Freitas, Rossimiriam P.,Skrydstrup, Troels
supporting information, p. 5775 - 5778 (2019/08/26)
Bench-stable tablets (COtabs) have been developed for the rapid and safe production of carbon monoxide. The tablets can be made in less than 5 min without the use of a glovebox and only require a stock solution of an amine base to liberate a specific quantity of CO in a two-chamber system. The COtabs were tested in five different carbonylation reactions and provided similar yields compared to literature procedures. Finally, a gram-scale reaction was conducted, as well as 13C-isotope labeling of the anticancer drug, olaparib.
Palladium-catalyzed carbonylative heck reaction of aryl bromides with vinyl ethers to 3-alkoxy alkenones and pyrazoles
Schranck, Johannes,Wu, Xiao-Feng,Neumann, Helfried,Beller, Matthias
supporting information; experimental part, p. 4827 - 4831 (2012/05/20)
Three COming together: The first carbonylative Heck coupling reaction of aryl bromides and vinyl ethers leading to 1-aryl-3-alkoxy-2-propen-1-ones has been established (see scheme). Based on this coupling methodology, a novel one-pot synthesis of aryl-substituted pyrazoles was also realized. Copyright
Palladium catalyzed carbonylative Heck reaction affording monoprotected 1,3-ketoaldehydes
Gogsig, Thomas M.,Nielsen, Dennis U.,Lindhardt, Anders T.,Skrydstrup, Troels
supporting information; experimental part, p. 2536 - 2539 (2012/08/14)
The direct carbonylative palladium catalyzed synthesis of monoprotected 1,3-ketoaldehydes is reported starting from aryl iodides applying near stoichiometric amounts of carbon monoxide. Besides representing platforms for a variety of heterocyclic structures, these motives serve as viable precursors for the highly relevant aryl methyl ketones. The presented strategy can also be adapted for the facile and efficient incorporation of 13C-labeled carbon monoxide.
Palladium-Catalyzed Aroylation of Alkyl Vinyl Ethers. An Entry to Monoprotected 1-Aryl-1,3-dicarbonyl Equivalents
Andersson, Carl-Magnus,Hallberg, Anders
, p. 4257 - 4263 (2007/10/02)
Reaction of aromatic and heteroaromatic acid chlorides with alkyl vinyl ethers in the presence of a palladium catalyst and an amine base gives the E-β-aroylated vinyl ethers 3 in moderate to good yield.The reaction proceeds under mild conditions and toler
