3672-48-8

Basic information

• Product Name: 5-(4-METHOXYPHENYL)ISOXAZOLE
• Synonyms: BUTTPARK 32\03-40;5-(4-METHOXYPHENYL)ISOXAZOLE
• CAS NO: 3672-48-8
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18
• Mol File: 3672-48-8.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(4-METHOXYPHENYL)ISOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-METHOXYPHENYL)ISOXAZOLE(3672-48-8)
• EPA Substance Registry System: 5-(4-METHOXYPHENYL)ISOXAZOLE(3672-48-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 3672-48-8(Hazardous Substances Data)

Usage

General Description

5-(4-Methoxyphenyl)isoxazole is a chemical compound with the molecular formula C10H9NO2. It is classified as an isoxazole, which is a five-membered heterocyclic ring containing one oxygen and one nitrogen atom. The compound has a molecular weight of 175.18 g/mol and is a pale yellow solid at room temperature. 5-(4-Methoxyphenyl)isoxazole is commonly used as a building block in organic synthesis and pharmaceutical research. It has also been studied for its potential biological activities, including its anti-inflammatory and analgesic properties. Additionally, it is known for its use in the synthesis of natural products and pharmaceuticals.

Upstream product

• 1533419-01-0 N'-((1-(4-methoxyphenyl)-3-oxoprop-1-en-1-yl)oxy)benzimidamide 
• 123-11-5 4-methoxy-benzaldehyde 
• 19115-30-1 1-(4-methoxyphenyl)-2-propyn-1-ol 
• 16469-68-4 1-(4-methoxyphenyl)-2-propyn-1-one 
• 37614-59-8 4-(4-methoxyphenyl)prop-2-yn-1-ol 
• 18096-70-3 3-dimethylamino-4'-methoxyacrylophenone 
• 91869-65-7 N-(α-methyl-4-methoxybenzylidenamino)-4,6-diphenyl-2-pyridone 
• 91869-62-4 1-[(E)-3-Dimethylamino-1-(4-methoxy-phenyl)-prop-2-en-(E)-ylideneamino]-4,6-diphenyl-1H-pyridin-2-one 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 31706-15-7 3-(4-methoxy-phenyl)-3-oxo-propionaldehyde 
• 62350-71-4 1-(p-Methoxy-benzoyl)-vinyl-alkohol 
• 18096-70-3 3-(dimethylamino)-1-(4-methoxyphenyl)prop-2-en-1-one 
• 53009-67-9 3-(4-methoxy-phenyl)-3-oxo-propionaldehyde-oxime 
• 115270-35-4 (E)-3-butoxy-1-(4-methoxyphenyl)prop-2-en-1-one 

Downstream Products

• 3672-47-7 3-oxo-3-(4'-methoxyphenyl)propanenitrile 
• 33064-24-3 5-(4-methoxyphenyl)-1-phenyl-1H-pyrazole 
• 33064-21-0 3-(4-methoxy-phenyl)-1-phenyl-1H-pyrazole 
• 19541-95-8 5-(4-methoxyphenyl)-1H-pyrazol-3-ylamine 

Relevant articles and documents

Cracking under internal pressure: Photodynamic behavior of vinyl azide crystals through N2release

When exposed to UV light, single crystals of the vinyl azides 3- azido-1-phenylpropenone (1a), 3-azido-1-(4-methoxyphenyl)propenone (1b), and 3-azido-1-(4-chlorophenyl)propenone (1c) exhibit dramatic mechanical effects by cracking or bending with the release of N2. Mechanistic studies using laser flash photolysis, supported by quantum mechanical calculations, show that each of the vinyl azides degrades through a vinylnitrene intermediate. However, despite having very similar crystal packing motifs, the three compounds exhibit distinct photomechanical responses in bulk crystals. While the crystals of 1a delaminate and release gaseous N2 indiscriminately under paraffin oil, the crystals of 1b and 1c visibly expand, bend, and fracture, mainly along specific crystallographic faces, before releasing N2. The photochemical analysis suggests that the observed expansion is due to internal pressure exerted by the gaseous product in the crystal lattices of these materials. Lattice energy calculations, supported by nanoindentation experiments, show significant differences in the respective lattice energies. The calculations identify critical features in the crystal structures of 1b and 1c where elastic energy accumulates during gas release, which correspond to the direction of the observed cracks. This study highlights the hitherto untapped potential of photochemical gas release to elicit a photomechanical response and motility of photoreactive molecular crystals.

A novel synthesis of 5-substituted isoxazoles from propargylic amines and N-hydroxyphthalimide

A mild and efficient method for the synthesis of 5-substituted isoxazoles through cyclization of propargylic amines with N-hydroxyphthalimide (NHPI) under metal-free conditions was developed.

An efficient synthesis of isoxazoles and pyrazoles under ultrasound irradiation

A series of 5-arylisoxazole and 5-aryl-1H-pyrazole derivatives was synthesized by the reaction of 3-(dimethylamino)-1-arylprop-2-en-1-one with hydroxylamine hydrochloride or hydrazine hydrate under ultrasound irradiation without using any catalyst. This m