115290-80-7

Upstream product

• 104196-23-8 (2S,3S)-2,3-epoxy-3-phenyl-1-propanol 
• 5764-85-2 Ethyl 3-hydroxy-3-phenylpropanoate 
• 118856-08-9 butyric acid 2-ethoxycarbonyl-1-phenyl-ethyl ester 
• 95-48-7 ortho-cresol 
• 115290-78-3 (1R) 3-phenyl-3-hydroxypropyl methanesulfonate 
• 100-52-7 benzaldehyde 
• 103548-16-9 (R)-3-phenyl-1,3-dihydroxypropane 
• 72656-47-4 ethyl (R)-3-hydroxy-3-phenylpropanoate 

Downstream Products

• 82857-39-4 -(+)-tomoxetine hydrochloride 
• 105314-53-2 (S)-N-methyl-3-(2-methylphenoxy)-3-phenyl-1-propanamine 

Relevant academic research and scientific papers

Asymmetric Synthesis of Both Enantiomers of Tomoxetine and Fluoxetine. Selective Reduction of 2,3-Epoxycinnamyl Alcohol with Red-Al.

Both enantiomers of tomoxetine 7a,7b and fluoxetine 8a,8b (as their hydrochloride salts) have been synthetized from cinnamyl alkohol by asymmetric epoxidation, and their absolute configurations have been established.Optimal conditions for regioselective Red-Al reduction at C-2 of 2,3-epoxycinnamyl alcohol are discussed.

Candida Rugosa lipase-catalyzed kinetic resolution of β-hydroxy- β-arylpropionates and δ-hydroxy-δ-aryl-β-oxo-pentanoates

A simple and convenient method was reported for the preparation of optically active β-hydroxy-β-arylpropionates, δ-hydroxy-δ- aryl-β-oxo-pentanoates and their butyryl derivatives via CRL-catalyzed hydrolysis. The optically active products are potential precursors of some chiral pharmaceuticals and natural products.