Journal of Organic Chemistry p. 4081 - 4084 (1988)
Update date:2022-07-30
Topics:
Gao, Y.
Sharpless, K. B.
Both enantiomers of tomoxetine 7a,7b and fluoxetine 8a,8b (as their hydrochloride salts) have been synthetized from cinnamyl alkohol by asymmetric epoxidation, and their absolute configurations have been established.Optimal conditions for regioselective Red-Al reduction at C-2 of 2,3-epoxycinnamyl alcohol are discussed.
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Doi:10.1016/S0040-4039(00)96880-1
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(1988)
