115293-13-5Relevant academic research and scientific papers
Molecular modeling and synthesis of new 1,5-diphenylpyrazoles as breast cancer cell growth inhibitors
Ewes, Wafaa A.,Badr, Sahar M.I.,Eisa, Hassan M.,Nasr, Magda N.A.
, p. 367 - 375 (2015)
New pyrazoles have been synthesized and evaluated as breast cancer cell growth inhibitors. Condensation of the substituted pyrazole-4-carbaldehyde 1 with acetophenone and chloroacetophenone afforded α, β-unsaturated ketones 2 and 3, respectively. Compounds 2 and 3 were subjected to different reactions using hydrazine hydrate, substituted hydrazine hydrate, hydroxylamine, o-phenylenediamine, malononitrile under different conditions affording 4-substituted pyrazole derivatives 4-28. Structure elucidation of these compounds was conducted using IR, 1H NMR, 13C NMR, mass spectral data and elemental analysis. Antitumor activity of target compounds was tested against MCF-7 cell line (human breast cancer). Compounds 4, 10 and 20 show significant antitumor activity against breast cancer. Docking was performed with protein 1UYK to study the binding mode of the designed compounds.
