115307-39-6

Upstream product

• 39228-29-0 (E)-methyl 2-nitrocinnamate 
• 612-41-9 2-nitrocinnamic acid 
• 88939-75-7 methyl (2E)-3-(2-aminophenyl)propenoate 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 115307-42-1 methyl 2-(4-methoxyphenyl)-3-quinolinecarboxylate 
• 1234713-32-6 [2-(4-methoxyphenyl)-1H-indol-3-yl]acetic acid methyl ester 

Relevant academic research and scientific papers

N-Heterocyclic carbene (NHC)-catalysed atom economical construction of 2,3-disubstituted indoles

A novel organocatalytic approach, harnessing the unique reactivities of N-heterocyclic carbenes (NHCs), has been revealed for the construction of indoles. The NHC-catalysed atom economical synthesis of a wide range of 2-substituted indole-3-acetic acid derivatives is displayed. Strategic application of the developed method was demonstrated for a short synthesis of a cyclin-dependent kinase (CDK) inhibitor: paullone.

A Convenient Synthesis of Substituted Quinolines by Thermal Electrocyclic Rearrangement of o-Vinyl Anils under Nonacidic Conditions

Anils 8a-g (Table II) underwent smooth rearrangement and oxidation to the quinolines 9a-g at 155-200 deg C via formation of the 2-3 carbon-carbon bond.These cyclizations proceeded in high yields under nonacidic conditions.It was often possible to prepare