A new DMAP-catalyzed phosphonamidite coupling reaction for synthesis of oligonucleotide methylphosphonate derivatives

Article abstract of DOI:10.1016/S0040-4039(00)94645-8

4-N,N-dimethylaminopyridine (DMAP) catalyzed coupling of 5′-dimethoxy-tritylthymidyl-3′-methylphosphonoamidite and 5′-trifluoroacetyl-3′-acetylthymidine and subsequent oxidation produce dinucleoside methyl phosphonate in a new, less water sensitive coupling reaction.