1154-84-3

Basic information

• Product Name: TRIMETHYLSILYL-N N-DIPHENYLUREA
• Synonyms: n,n’-diphenyl-n-(trimethylsilyl)-ure;N,N’-diphenyl-N-(trimethylsilyl)-Urea;N-Trimethylsilyl-N,N’-diphenylurea;TRIMETHYLSILYL-N N-DIPHENYLUREA;TRIMETHYLSILYL-N,N'-DIPHENYLUREA;1,3-diphenyl-1-(trimethylsilyl)urea;Urea,N,N'-diphenyl-N-(trimethylsilyl)-
• CAS NO: 1154-84-3
• Molecular Formula: C₁₆H₂₀N₂OSi
• Molecular Weight: 284.43
• EINECS: 214-578-9
• Mol File: 1154-84-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.106g/cm³
• CAS DataBase Reference: TRIMETHYLSILYL-N N-DIPHENYLUREA(CAS DataBase Reference)
• NIST Chemistry Reference: TRIMETHYLSILYL-N N-DIPHENYLUREA(1154-84-3)
• EPA Substance Registry System: TRIMETHYLSILYL-N N-DIPHENYLUREA(1154-84-3)

Safety Data

• Hazardous Substances Data: 1154-84-3(Hazardous Substances Data)

Usage

General Description

TRIMETHYLSILYL-N N-DIPHENYLUREA is a chemical compound with the molecular formula C14H20N2OSi. It is commonly used as a reagent in organic synthesis and as a protecting group for amines and alcohols. TRIMETHYLSILYL-N N-DIPHENYLUREA is known for its ability to efficiently convert carboxylic acids to amides in the presence of a base, making it a valuable tool in peptide and pharmaceutical synthesis. It is also utilized in the preparation of a variety of organic compounds through its ability to selectively modify specific functional groups. TRIMETHYLSILYL-N N-DIPHENYLUREA has found widespread application in the field of synthetic chemistry due to its versatility and compatibility with a wide range of reaction conditions.

Upstream product

• 103-71-9 phenyl isocyanate 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 3768-55-6 N-trimethylsilylaniline 

Downstream Products

• 176504-71-5 N-trimethylsilyl-O-2,4-dinitrophenylhydroxylamine 
• 14635-37-1 2.4.6-(Trimethylsilyl-amino)-1.3.5-tricyan-benzol 

Relevant articles and documents

Insertion of phenyl isocyanate into monoand diaminosilanes

The aminosilanes MenSi(NRR')4-n (n = 2,3) with NRR' = ethylamino (NHEt), n-propylamino (NHnPr), sec-butylamino (NHsBu), n-octylamino (NHnOct), n-dodecylamino (NHnDodec), allylamino (NHAll), tert-butylamino (NHtBu), diethylamino (NEt2), and anilino (NHPh) were synthesized and their reactions with phenyl isocyanate were studied. In all cases of these silanes Me3SiNRR' and Me2Si(NRR')2 formal insertion of the -NCO group into their Si-N bonds was observed, i.e. formation of products with Si-N (rather than Si-O) bonds was found. In some cases, the products could be crystallized and their molecular structures have been elucidated with single-crystal X-ray diffraction analyses.