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TRIMETHYLSILYL-N N-DIPHENYLUREA, with the molecular formula C14H20N2OSi, is a versatile chemical compound widely recognized for its utility in organic synthesis. It serves as an effective reagent and a protecting group for amines and alcohols, showcasing its ability to efficiently convert carboxylic acids to amides in the presence of a base. This characteristic makes it an indispensable tool in the realms of peptide and pharmaceutical synthesis, as well as in the preparation of various organic compounds through selective functional group modification. Its compatibility with a broad spectrum of reaction conditions has solidified its position in synthetic chemistry.

1154-84-3

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1154-84-3 Usage

Uses

Used in Organic Synthesis:
TRIMETHYLSILYL-N N-DIPHENYLUREA is used as a reagent for its ability to selectively modify specific functional groups in organic compounds, facilitating the synthesis of a wide range of organic molecules.
Used in Peptide and Pharmaceutical Synthesis:
In the pharmaceutical industry, TRIMETHYLSILYL-N N-DIPHENYLUREA is utilized as a protecting group for amines and alcohols, and for its capacity to convert carboxylic acids to amides, which is crucial for the formation of peptide bonds in drug development.
Used in the Preparation of Organic Compounds:
TRIMETHYLSILYL-N N-DIPHENYLUREA is employed as a key component in the synthesis of various organic compounds due to its versatility and compatibility with diverse reaction conditions, making it a valuable asset in the field of synthetic chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 1154-84-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,5 and 4 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1154-84:
(6*1)+(5*1)+(4*5)+(3*4)+(2*8)+(1*4)=63
63 % 10 = 3
So 1154-84-3 is a valid CAS Registry Number.

1154-84-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name TRIMETHYLSILYL-N N-DIPHENYLUREA

1.2 Other means of identification

Product number -
Other names trimethylsilyl-N,N'-diphenyl-urea

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1154-84-3 SDS

1154-84-3Relevant academic research and scientific papers

Insertion of phenyl isocyanate into monoand diaminosilanes

Kraushaar, Konstantin,Herbig, Marcus,Schmidt, Dana,Wagler, J?rg,B?hme, Uwe,Kroke, Edwin

, p. 909 - 921 (2018/01/19)

The aminosilanes MenSi(NRR')4-n (n = 2,3) with NRR' = ethylamino (NHEt), n-propylamino (NHnPr), sec-butylamino (NHsBu), n-octylamino (NHnOct), n-dodecylamino (NHnDodec), allylamino (NHAll), tert-butylamino (NHtBu), diethylamino (NEt2), and anilino (NHPh) were synthesized and their reactions with phenyl isocyanate were studied. In all cases of these silanes Me3SiNRR' and Me2Si(NRR')2 formal insertion of the -NCO group into their Si-N bonds was observed, i.e. formation of products with Si-N (rather than Si-O) bonds was found. In some cases, the products could be crystallized and their molecular structures have been elucidated with single-crystal X-ray diffraction analyses.

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