53796-61-5

Basic information

• Product Name: N-acetyl-O-methyl-tyrosine
• Synonyms: N-acetyl-O-methyl-tyrosine
• CAS NO: 53796-61-5
• Molecular Weight: 237.255
• Mol File: 53796-61-5.mol

Chemical Properties

• CAS DataBase Reference: N-acetyl-O-methyl-tyrosine(CAS DataBase Reference)
• NIST Chemistry Reference: N-acetyl-O-methyl-tyrosine(53796-61-5)
• EPA Substance Registry System: N-acetyl-O-methyl-tyrosine(53796-61-5)

Safety Data

• Hazardous Substances Data: 53796-61-5(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 7635-29-2 O-methyl tyrosine 
• 108-24-7 acetic anhydride 
• 6230-11-1 O-Methyltyrosine 
• 71198-72-6 4-[(4-methoxyphenyl)methylene]-2-methyl-5(4H)-oxazolone 

Downstream Products

• 1570061-47-0 C₁₈H₂₅N₃O₆ 
• 1570061-50-5 C₂₁H₃₀N₄O₇ 
• 1570061-52-7 C₂₄H₃₅N₅O₈ 
• 115424-09-4 N-Cbz-2-(4-methoxyphenyl)-1-methylethylamine 
• 115424-07-2 [(S)-1-Iodomethyl-2-(4-methoxy-phenyl)-ethyl]-carbamic acid benzyl ester 
• 115424-06-1 Toluene-4-sulfonic acid (S)-2-benzyloxycarbonylamino-3-(4-methoxy-phenyl)-propyl ester 
• 115424-05-0 (S)-benzyl (1-hydroxy-3-(4-methoxyphenyl)propan-2-yl)carbamate 
• 115424-04-9 N-benzyloxycarbonylamino-3-(4-methoxyphenyl)propionic acid ethyl ester 
• 6330-11-6 O-methyl-L-tyrosine ethyl ester; hydrochloride 
• 6230-11-1 O-Methyltyrosine 
• 39878-65-4 (R)-β-(4-methoxyphenyl)alanine 
• 17355-19-0 methyl (S)-2-amino-3-(4-methoxyphenyl)propionate 

Relevant articles and documents

Minisci-Type Alkylation of N-Heteroarenes by N-(Acyloxy)phthalimide Esters Mediated by a Hantzsch Ester and Blue LED Light

A synthetic method that enables the Hantzsch ester-mediated Minisci-type C2-alkylation of quinolines, isoquinolines and pyridines by N-(acyloxy)phthalimide esters (NHPI) under blue LED (light emitting diode) light (456 nm) is described. Achieved under mild reaction conditions at room temperature, the metal-free synthetic protocol was shown to be applicable to primary, secondary and tertiary NHPIs to give the alkylated N-heterocyclic products in yields of 21–99%. On introducing a chiral phosphoric acid, an asymmetric version of the reaction was also realised and provided product enantiomeric excess (ee) values of 53–99%. The reaction mechanism was delineated to involve excitation of an electron-donor acceptor (EDA) complex, formed from weak electrostatic interactions between the Hantzsch ester and NHPI, which generates the posited radical species of the redox active ester that undergoes addition to the N-heterocycle.

Diastereoselectivity in prebiotically relevant 5(4H)-oxazolone-mediated peptide couplings

A stereochemical study of a potentially prebiotic peptide-forming reaction was carried out as the first part of a systems chemistry investigation of potential paths for symmetry breaking. Substantial diastereomeric excesses result from a fast epimerization of the 5(4H)-oxazolone intermediate in aqueous solution. The Royal Society of Chemistry.

Optimisation and synthesis of libraries derived from phenolic amino acid scaffolds

Functionalisation of a series of resin bound phenolic amino acids is described, employing Irori technology to produce multidimensional libraries. (C) 2000 Elsevier Science Ltd.

Composition containing a penem or carbapenem antibiotic

Administration of an N-acylated amino acid in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid derivative and antibiotic may be formulated together as a composition or administered separately, either simultaneously or sequentially. The composition may be prepared by simple mixing.