115438-86-3

Upstream product

• 3382-18-1 6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 88-95-9 Phthaloyl dichloride 
• 4885-02-3 Dichloromethyl methyl ether 
• 26477-09-8 N-2-(3,4-dimethoxyphenyl)ethylphthalimide 

Downstream Products

• 113557-25-8 2-[2-(2-tert-Butylsulfanylmethyl-4,5-dimethoxy-phenyl)-ethyl]-isoindole-1,3-dione 
• 138344-91-9 3-Butyl-2-[2-(2-[1,3]dithian-2-yl-4,5-dimethoxy-phenyl)-ethyl]-3-hydroxy-2,3-dihydro-isoindol-1-one 
• 138344-92-0 N-<2-(1,3-dithian-2-yl)-4,5-dimethoxyphenethyl>phthalimide S-oxide 
• 138344-99-7 N-[2-(2-[1,3]Dithian-2-yl-4,5-dimethoxy-phenyl)-ethyl]-2-pentanoyl-benzamide 
• 115438-87-4 N-<2-(1,3-dithiolan-2-yl)-4,5-dimethoxyphenethyl>phthalimide 
• 115438-88-5 N-<2-(1,3-dithian-2-yl)-4,5-dimethoxyphenethyl>phthalimide 

Relevant academic research and scientific papers

A PHOTOCHEMICAL APPROACH TO THE FULLY FUNCTIONALIZED RING SYSTEM OF CHILINENE, A KEY ALKALOID OF THE BERBERINE FAMILY

The fully functionalized ring system of the berberine alkaloid chilinene has been prepared in a seven step synthesis.Key steps in the synthesis are the photocyclization of an imide-thioether and the oxidative formation with Pb(OAc)4 of a novel hexacyclic orthoester which led directly to the desired product.

AN INTERESTING APPLICATION OF PHOTOCYCLISATION IN APORHOEADANE ALKALOID SYNTHESIS

Reaction of 2-carboethoxybenzoyl chloride with 3,4-dihydro-6,7-dimethoxyisoquinoline afforded a ring open aldehydic phtalimide (3) which on thioacetal formation and photocyclisation followed by deketalisation gave 8,14-dioxo-13-hydroxyaporhoeadane (8).