937013-96-2

Usage

Uses

Used in Pharmaceutical Industry:
4-bromo-6-fluoro-1H-benzo[d][1,2,3]triazole is used as a building block for the development of novel drugs and therapeutic agents. Its unique structure and properties make it a promising candidate for the creation of new pharmaceutical compounds with potential therapeutic benefits.
Used in Materials Science:
In the field of materials science, 4-bromo-6-fluoro-1H-benzo[d][1,2,3]triazole may be utilized in the design and synthesis of new materials with specific properties. Its chemical structure can contribute to the development of advanced materials with applications in various industries.
Used in Organic Synthesis:
4-bromo-6-fluoro-1H-benzo[d][1,2,3]triazole is also used as an intermediate in organic synthesis. Its presence in the molecular structure allows for further chemical reactions and modifications, enabling the synthesis of a wide range of organic compounds for various applications.
The specific properties and potential uses of 4-bromo-6-fluoro-1H-benzo[d][1,2,3]triazole make it a subject of interest for further research and study, as it may lead to the discovery of new applications and advancements in multiple fields.

Upstream product

• 115440-10-3 3-bromo-5-fluoro-1,2-phenylenediamine 
• 364-78-3 2-nitro-4-fluoroaniline 
• 371-40-4 4-fluoroaniline 
• 344-18-3 2,6-dibromo-4-fluoroaniline 

Relevant academic research and scientific papers

FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF PAIN

Provided herein are compounds that are useful in the treatment of pain in a subject. Also provided herein is a pharmaceutical composition comprising compounds or pharmaceutically acceptable salts thereof, and a pharmaceutically acceptable carrier and methods of treating pain in a subject in need thereof.

Making endo-cyclizations favorable again: A conceptually new synthetic approach to benzotriazoles via azide group directed lithiation/cyclization of 2-azidoaryl bromides

Although benzotriazoles are important and ubiquitous, currently there is only one conceptual approach to their synthesis: bridging the two ortho-amino groups with an electrophilic nitrogen atom. Herein, we disclose a new practical alternative-the endo-cyclization of 2-azidoaryl lithiums obtained in situ from 2-azido-aryl bromides. The scope of the reaction is illustrated using twenty-four examples with a variety of alkyl, alkoxy, perfluoroalkyl, and halogen substituents. We found that the directing effect of the azide group allows selective metal-halogen exchange in aryl azides containing several bromine atoms. Furthermore, (2-bromophenyl)diazomethane undergoes similar cyclization to give an indazole. Thus, cyclizations of aryl lithiums containing an ortho-X = Y = Z group emerge as a new general approach for the synthesis of aromatic heterocycles. DFT computations suggested that the observed endo-selectivity applies to the anionic cyclizations of other functionalities that undergo "1,1-additions" (i.e., azides, diazo compounds, and isonitriles). In contrast, cyclizations with the heteroatomic functionalities that follow the "1,2-addition" pattern (cyanates, thiocyanates, isocyanates, isothiocyanates, and nitriles) prefer the exo-cyclization path. Hence, such reactions expand the current understanding of stereoelectronic factors in anionic cyclizations.