115444-95-6

Upstream product

• 102493-68-5 2-(2-chloro-6-nitrophenyl)-ethanol 
• 124-63-0 methanesulfonyl chloride 
• 83-42-1 6-chloro-2-nitrotoluene 

Downstream Products

• 301645-40-9 1-chloro-3-nitro-2-vinylbenzene 
• 25235-85-2 4-chloro-1H-indole 
• 773880-62-9 N-allyl-N-p-toluenesulfonyl-3-chloro-2-vinylaniline 
• 773880-75-4 N-p-toluenesulfonyl-3-chloro-2-ethenylaniline 

Relevant academic research and scientific papers

Cycloisomerization promoted by the combination of a ruthenium-carbene catalyst and trimethylsilyl vinyl ether, and its application in the synthesis of heterocyclic compounds: 3-Methylene-2,3-dihydroindoles and 3-methylene-2,3- dihydrobenzofurans

Substituted N and O heterocycles have been synthesized by the cycloisomerization of dienes using a ruthenium-carbene catalyst. The products obtained with and without trimethylsilyl vinyl ether differ (see scheme, Cy = cyclohexyl, Mes = 2,4,6-trimethylphenyl, Ts = p-toluenesulfonyl).

Pd-tBuONO Cocatalyzed Aerobic Indole Synthesis

A Pd-tBuONO co-catalyzed scalable and practical synthesis of indoles with molecular oxygen as terminal oxidant is developed. Either terminal or internal 2-vinylanilines could be smoothly converted to desired indoles under one general condition. This method has been evaluated in the large scale synthesis of indomethacin and a potential anti-breast cancer drug candidate 1. (Figure presented.).

A new method for the synthesis of 2,6-dinitro and 2-halo-6-nitrostyrenes

A new method for the synthesis of 2-halo-6-nitrostyrenes from 2-halo-6-nitrotoluenes is disclosed. Also described is a one-pot process for the synthesis of 2,6-dinitristyrene from 2,6-dinitrotoluene. (C) 2000 Elsevier Science Ltd.