301645-40-9

Upstream product

• 115444-95-6 2-chloro-6-nitrophenethyl methanesulfonate 
• 179691-39-5 5'-O-(2-(2-chloro-6-nitrophenyl)ethoxycarbonyl)thymidine 
• 83-42-1 6-chloro-2-nitrotoluene 
• 102493-68-5 2-(2-chloro-6-nitrophenyl)-ethanol 

Downstream Products

• 90006-42-1 2-ethyl-3-chloro-aniline 
• 72995-15-4 5-chloro-3,4-dihydro-2(1H)-quinolinone 
• 25235-85-2 4-chloro-1H-indole 
• 773880-75-4 N-p-toluenesulfonyl-3-chloro-2-ethenylaniline 
• 773880-62-9 N-allyl-N-p-toluenesulfonyl-3-chloro-2-vinylaniline 
• 102855-24-3 4-chloro-1-tosyl-1H-indole 

Relevant academic research and scientific papers

Pd-tBuONO Cocatalyzed Aerobic Indole Synthesis

A Pd-tBuONO co-catalyzed scalable and practical synthesis of indoles with molecular oxygen as terminal oxidant is developed. Either terminal or internal 2-vinylanilines could be smoothly converted to desired indoles under one general condition. This method has been evaluated in the large scale synthesis of indomethacin and a potential anti-breast cancer drug candidate 1. (Figure presented.).

Development of isomerization and cycloisomerization with use of a ruthenium hydride with N-heterocyclic carbene and its application to the synthesis of heterocycles

A pure ruthenium hydride complex with N-heterocyclic carbene (NHC) ligand was efficiently generated from the reaction of a second-generation Grubbs ruthenium catalyst with vinyloxytrimethylsilane and unambiguously characterized. This ruthenium hydride complex showed high catalytic activity for the selective isomerization of terminal olefin and for the cycloisomerization of 1,6-dienes. These reactions of N-allyl-o-vinylaniline lead to novel synthetic methods for heterocycles such as indoles and 3-methylene-2,3-dihydroindoles, which are useful synthons for bioactive natural products. These procedures address an important issue in diversity-oriented synthesis.

Cycloisomerization promoted by the combination of a ruthenium-carbene catalyst and trimethylsilyl vinyl ether, and its application in the synthesis of heterocyclic compounds: 3-Methylene-2,3-dihydroindoles and 3-methylene-2,3- dihydrobenzofurans

Substituted N and O heterocycles have been synthesized by the cycloisomerization of dienes using a ruthenium-carbene catalyst. The products obtained with and without trimethylsilyl vinyl ether differ (see scheme, Cy = cyclohexyl, Mes = 2,4,6-trimethylphenyl, Ts = p-toluenesulfonyl).

Photolabile protecting groups for nucleosides: Mechanistic studies of the 2-(2-nitrophenyl)ethyl group

The photochemistry of several 2-(2-nitrophenyl)ethyl-caged compounds including caged thymidine nucleosides was studied by nanosecond laser flash photolysis and stationary illumination experiments with quantitative HPLC analysis for quantum yields and prod

A new method for the synthesis of 2,6-dinitro and 2-halo-6-nitrostyrenes

A new method for the synthesis of 2-halo-6-nitrostyrenes from 2-halo-6-nitrotoluenes is disclosed. Also described is a one-pot process for the synthesis of 2,6-dinitristyrene from 2,6-dinitrotoluene. (C) 2000 Elsevier Science Ltd.