115445-23-3

Basic information

• Product Name: 1-BENZYL-3-(TRIFLUOROACETAMIDO)PYRROLIDINE
• Synonyms: 1-BENZYL-3-(TRIFLUOROACETAMIDO)PYRROLIDINE;1-BENZYL-3-(TRIFLUOROACETAMIDO)PYRROLIDINE 96+%;1-Benzyl-3-(trifluoroacetylamino)pyrrolidine;2,2,2-Trifluoro-N-(1-benzyl-3-pyrrolidinyl)acetamide;N-(1-Benzylpyrrolidin-3-yl)-2,2,2-trifluoroacetamide
• CAS NO: 115445-23-3
• Molecular Formula: C13H15F3N2O
• Molecular Weight: 272.27
• Product Categories: 3-Aminopyrrolidines;3-Aminopyrrolidines (Racemic)
• Mol File: 115445-23-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 71 °C
• Boiling Point: 345.1°Cat760mmHg
• Flash Point: 162.5°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 6.32E-05mmHg at 25°C
• Refractive Index: 1.52
• CAS DataBase Reference: 1-BENZYL-3-(TRIFLUOROACETAMIDO)PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-3-(TRIFLUOROACETAMIDO)PYRROLIDINE(115445-23-3)
• EPA Substance Registry System: 1-BENZYL-3-(TRIFLUOROACETAMIDO)PYRROLIDINE(115445-23-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 115445-23-3(Hazardous Substances Data)

Usage

General Description

1-Benzyl-3-(trifluoroacetamido)pyrrolidine is a synthetic chemical compound used in research and pharmaceutical development. It is a pyrrolidine derivative with a trifluoroacetamide group attached to the third carbon and a benzyl group attached to the first carbon of the pyrrolidine ring. 1-BENZYL-3-(TRIFLUOROACETAMIDO)PYRROLIDINE has potential applications in medicinal chemistry, particularly in the development of drugs targeting the central nervous system. It may also be used as a building block in the synthesis of other complex molecules. However, its exact uses and potential effects have not been extensively studied, and further research is needed to fully understand its properties and applications.

InChI:InChI=1/C13H15F3N2O/c14-13(15,16)12(19)17-11-6-7-18(9-11)8-10-4-2-1-3-5-10/h1-5,11H,6-9H2,(H,17,19)

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 114715-39-8 (R)-1-benzyl-3-aminopyrrolidine 
• 407-25-0 trifluoroacetic anhydride 
• 114715-38-7 (3S)-1-benzyl-3-pyrrolidinamine 
• 202267-01-4 (1S,2R,3S,4R)-2,3-dihydroxy-4-[6-[1-(4-trifluormethylpyridin-2-yl)pyrrolidin-3(S)-ylamino]purin-9-yl]cyclopentanecarboxylic acid isopropylamide 

Downstream Products

• 499774-45-7 2,2,2-trifluoro-N-pyrrolidin-3-yl-acetamide 

Relevant articles and documents

Enantiomeric impurities in chiral synthons, catalysts, and auxiliaries: Part 3

The enantiomeric excess of chiral reagents used in asymmetric syntheses directly affects the reaction selectivity and product purity. In this work, 84 of the more recently available chiral compounds were evaluated to determine their actual enantiomeric composition. These compounds are widely used in asymmetric syntheses as chiral synthons, catalysts, and auxiliaries. These include chiral alcohols, amines, amino alcohols, amides, carboxylic acids, epoxides, esters, ketones, and oxolanes among other classes of compounds. All enantiomeric test results were categorized within five impurity levels (i.e., 10%). The majority of the reagents tested were determined to have enantiomeric impurities over 0.01%, and two of them were found to contain enantiomeric impurities exceeding the 10% level. The most effective enantioselective analysis method was a GC approach using a Chiraldex GTA chiral stationary phase (CSP). This method worked exceedingly well with chiral amines and alcohols.

Methods of treating insulin resistance syndrome and diabetes

This invention is directed to methods of treating insulin resistance syndrome and diabetes in a patient in need thereof, comprising administering to said patient a pharmaceutically effective amount of a compound derived from adenosine and analogues thereof, or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable prodrug thereof, an N-oxide thereof, a hydrate thereof or a solvate thereof, or a pharmaceutical composition comprising such compound.