115462-72-1Relevant academic research and scientific papers
Aryloxymethyl derivatives of nitrogenous heterocyclic methanols and ethers thereof
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, (2008/06/13)
Novel heterocyclicmethanols are disclosed having the formula: STR1 wherein Z is pyrrolidinyl, piperidinyl, homopiperidinyl or pyridinyl; R1 is hydrogen, loweralkyl or carbethoxymethyl; R2 is hydrogen, loweralkyl, cycloalkyl, phenyl or phenyl-loweralkyl; R3 is 1 or 2-naphthalenyl, 2,3-dihydroinden-4 or 5-yl, phenyl or phenyl substituted by loweralkyl, loweralkoxy, halogen, trifluoromethyl, phenyl, methylenedioxy, nitro, amino, loweralkylamino, diloweralkylamino, loweracylamino; the 1-position of 2-pyrrolidinyl, 2-piperidinyl or 2-homopiperidinyl may be substituted by an R4 loweralkyl group, or R1 may form methylene or --CH2 -C(O)-bridges with R4 ; the pharmaceutically acceptable salts and diastereomers thereof, which compounds have antiarrhythmic and/or hypotensive activity in animals.
Synthesis of 2-aryloxy- and 2-arylalkoxy-1-(2-piperidyl)ethanols
Mauleon,Dolors Pujol,Minguillon,Miquel
, p. 693 - 699 (2007/10/02)
The preparation and separation of diastereomeric pairs of a series of 2-aryloxy- and 2-arylalkoxy-1-(2-piperidyl)ethanols is reported. The erythro aminoalcohols were converted into threo isomers by thionyl chloride treatment of their N-acetyl derivatives
