115678-07-4

Upstream product

• 78699-85-1 2,3,4,5,6-penta-O-benzyl-aldehydo-D-glucose 
• 115704-95-5 2,3,4,5,6-penta-O-benzyl-D-glucose diethyl dithioacetal 
• 100-39-0 benzyl bromide 

Downstream Products

• 115678-16-5 2,3,4,5,6-penta-O-benzyl-1-O-(3,4-di-O-benzyl-α-L-rhamnopyranosyl)-D-glucitol 
• 115678-23-4 1-O-<2-O-(2-O-benzoyl-3,4-di-O-benzyl-α-L-rhamnopyranosyl)-3,4-di-O-benzyl-α-L-rhamnopyranosyl>-2,3,4,5,6-penta-O-benzyl-D-glucitol 
• 115678-23-4 1-O-<2-O-(2-O-benzoyl-3,4-di-O-benzyl-α-L-rhamnopyranosyl)-3,4-di-O-benzyl-β-L-rhamnopyranosyl>-2,3,4,5,6-penta-O-benzyl-D-glucitol 
• 115678-15-4 1-O-(2-O-acetyl-3,4-di-O-benzyl-α-L-rhamnopyranosyl)-2,3,4,5,6-penta-O-benzyl-D-glucitol 

Relevant academic research and scientific papers

Discovery of Oligosaccharide Antigens for Semi-Synthetic Glycoconjugate Vaccine Leads against Streptococcus suis Serotypes 2, 3, 9 and 14**

Streptococcus suis bacteria are one of the most serious health problems for pigs and an emerging zoonotic agent in humans working in the swine industry. S. suis bacteria express capsular polysaccharides (CPS) a major bacterial virulence factor that define the serotypes. Oligosaccharides resembling the CPS of S. suis serotypes 2, 3, 9, and 14 have been synthesized, glycans related to serotypes 2 and 9 were placed on glycan array surfaces to screen blood from infected pigs. Lead antigens for the development of semi-synthetic S. suis serotypes 2 and 9 glycoconjugate veterinary vaccines were identified in this way.

Synthesis of Oligosaccharides Corresponding to the Common Polysaccharide Antigen of Group B Streptococci

To facilitate mapping of the immunodominant region of the common polysaccharide antigen of group B streptococci, tetrasaccharide 1-O--α-rhamnopyranosyl>-D-glucitol (2) was synthesized in a stepwise fasion