115704-95-5

Upstream product

• 1941-52-2 D-glucose diethyl mercaptal 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 50-99-7 D-glucose 
• 2280-44-6 D-Glucose 
• 1941-52-2 D-glucose diethyl dithioacetal 

Downstream Products

• 115678-15-4 1-O-(2-O-acetyl-3,4-di-O-benzyl-α-L-rhamnopyranosyl)-2,3,4,5,6-penta-O-benzyl-D-glucitol 
• 115678-16-5 2,3,4,5,6-penta-O-benzyl-1-O-(3,4-di-O-benzyl-α-L-rhamnopyranosyl)-D-glucitol 
• 115678-07-4 2,3,4,5,6-penta-O-benzyl-D-glucitol 
• 78699-85-1 2,3,4,5,6-penta-O-benzyl-aldehydo-D-glucose 
• 121682-98-2 1,3-dibenzyloxy-5-benzyloxymethyl-4-<(1RS,2R,3S,4R,5R)-1-hydroxy-2,3,4,5,6-pentabenzyloxyhexyl> benzene 
• 121709-48-6 1,3-dibenzyloxy-5-benzyloxymethyl-4-<(2R,3S,4R,5R)-2,3,4,5,6-pentabenzyloxy-1-hexanonyl> benzene 
• 121682-96-0 5-benzyloxy-1,3-dimethoxy-4-<(1RS,2R,3S,4R,5R)-1-hydroxy-2,3,4,5,6-pentabenzyloxyhexyl> benzene 
• 121683-00-9 5-benzyloxymethyl-1,3-dimethoxy-4-<(2R,3S,4R,5R)-2,3,4,5,6-penta-benzyloxy-1-hexanonyl> benzene 
• 121682-95-9 methyl 2,3,4,5,6-penta-O-benzyl-D-gluconate 
• 121682-94-8 2,3,4,5,6-penta-O-benzyl-D-gluconic acid 
• 78699-85-1 2,3,4,5,6-penta-O-benzyl-D-glucose 

Relevant academic research and scientific papers

Regioselective Synthesis of Difluorinated C-Furanosides Involving a Debenzylative Cycloetherification

A highly regioselective synthesis of valuable gem-difluorinated C-furanosides from unprotected aldoses via a debenzylative cycloetherification (DBCE) reaction induced by diethylaminosulfur trifluoride is descibed. The scope and limitations of this DBCE reaction are described using a series of commercially available pentoses and hexoses to afford, without selective protection/deprotection sequences, the corresponding gem-difluorinated C-furanosides in moderate to good yields.

Efficient and regioselective synthesis of γ-lactone glycosides through a novel debenzylative cyclization reaction

An efficient and regioselective approach for the construction of synthetically important γ-lactone glycosides is reported from unprotected aldoses through a new debenzylative lactonization (DBL) reaction. The scope and limitations of this DBL reaction are described starting from a series of commercially available hexoses (l-fucose, d-galactose, d-glucose) and pentoses (d-arabinose, d-ribose, d-lyxose, d-xylose) to afford the corresponding γ-lactones in good yields and without concomitant δ-lactone formation.

Dapagliflozin impurity synthesis method

The invention discloses a dapagliflozin impurity synthesis method. The synthesis method includes: using D-glucose as a raw material; subjecting the D-glucose to reactions of aldehyde group protection through ethanethiol, benzyl group adding, ethanethiol removal, condensation and benzyl group removal to obtain dapagliflozin impurities. A basis is provided for study of dapagliflozin related substances.

IMPROVED NUCLEOPHILIC DISPLACEMENTS IN N-METHYL PYRROLIDINONE AS A SOLVENT

The nucleophilic displacement reactions of 2- and 4-halogenonaphthalic-1,8-anhydrides and the N-imides, of 4,7-dichloroquinolines, the alkylation of lithio alkynes, the methylation of ethyl or methyl diacetylacetate and a variety of related reactions are greatly facilitated in N-methylpyrrolidinone as aprotic solvent.

Synthesis of Oligosaccharides Corresponding to the Common Polysaccharide Antigen of Group B Streptococci

To facilitate mapping of the immunodominant region of the common polysaccharide antigen of group B streptococci, tetrasaccharide 1-O--α-rhamnopyranosyl>-D-glucitol (2) was synthesized in a stepwise fasion

SHORT SYNTHESIS OF C-ARYL-GLUCOPYRANOSIDES OF THE PAPULACANDIN TYPE

The aryllithium species 5a-A and 5b-A generated via bromine/lithium exchange reaction, afforded with the per-O-benzylated D-glucose 6 the adducts 9a,b; subsequent oxidation furnished the corresponding ketones 10a,b.Compound 10a was also obtained from 5a-A