1156840-85-5

Basic information

• Product Name: C₁₁H₁₅NO₄S
• CAS NO: 1156840-85-5
• Molecular Weight: 257.31
• Mol File: 1156840-85-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₁H₁₅NO₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₁H₁₅NO₄S(1156840-85-5)
• EPA Substance Registry System: C₁₁H₁₅NO₄S(1156840-85-5)

Safety Data

• Hazardous Substances Data: 1156840-85-5(Hazardous Substances Data)

Upstream product

• 4025-71-2 2-phenylethylsulfonyl chloride 
• 616-34-2 methoxycarbonylmethylamine 
• 13552-93-7 sodium 2-phenylethane-1-sulfonate 
• 103-63-9 1-phenyl-2-bromoethane 
• 60-12-8 2-phenylethanol 

Downstream Products

• 1433543-50-0 N-hydroxy-2-(2-phenylethylsulfonamido)acetamide 

Relevant articles and documents

Discovery of a new class of potent MMP inhibitors by structure-based optimization of the arylsulfonamide scaffold

A new class of potent matrix metalloproteinase (MMP) inhibitors designed by structure-based optimization of the well-known arylsulfonamide scaffold is presented. Molecules show an ethylene linker connecting the sulfonamide group with the P1' aromatic portion and a D-proline residue bearing the zinc-binding group. The affinity improvement provided by these modifications led us to discover a nanomolar MMP inhibitor bearing a carboxylate moiety as zinc-binding group, which might be a promising lead molecule. Notably, a significant selectivity for MMP-8, MMP-12, and MMP-13 was observed with respect to MMP-1 and MMP-7.