1157-94-4

Basic information

• Product Name: Isoxazole, 5-(2-naphthalenyl)-3-phenyl-
• CAS NO: 1157-94-4
• Molecular Formula: C19H13NO
• Molecular Weight: 271.318
• Mol File: 1157-94-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Isoxazole, 5-(2-naphthalenyl)-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoxazole, 5-(2-naphthalenyl)-3-phenyl-(1157-94-4)
• EPA Substance Registry System: Isoxazole, 5-(2-naphthalenyl)-3-phenyl-(1157-94-4)

Safety Data

• Hazardous Substances Data: 1157-94-4(Hazardous Substances Data)

Upstream product

• 2168-78-7 methyl dithiobenzoate 
• 93-08-3 methyl 2-naphthyl ketone 
• 15473-67-3 1-(naphthalen-3-yl)-3-phenyl-3-thioxopropan-1-one 
• 32316-92-0 naphthalene-2-boronic acid 
• 454253-30-6 trifluoromethanesulfonic acid 3-phenyl-isoxazol-5-yl ester 
• 1076-59-1 3-phenyl-4H-isoxazol-5-one 
• 16736-88-2 1-(naphthalen-2-yl)-3-phenylprop-2-yn-1-one 
• 57114-80-4 1-(naphthalen-2-yl)-3-phenyl-propan-1,3-dione 
• 7803-49-8 hydroxylamine 

Relevant articles and documents

3, 5-disubstituted isoxazole derivative and synthesis method thereof

The invention provides a 3, 5-disubstituted isoxazole derivative and a synthesis method thereof, and belongs to the technical field of organic synthesis medicines and medical intermediates. The method comprises the following steps: adding a proper solvent

Copper-catalyzed aerobic oxidative C-O bond formation for the synthesis of 3,5-disubstituted isoxazoles from enone oximes

A direct access to 3,5-disubstituted isoxazoles has been accomplished through an intramolecular oxidative coupling reaction of enone oximes using a catalytic quantity of Cu(OAc)2. This method features an inexpensive metal catalyst, molecular ox

Cyclocondensation of hydroxylamine with 1,3-bis(het)arylmonothio 1,3-diketones and 1,3-bis(het)aryl-3-(methylthio)-2-propenones: Synthesis of 3,5-bis(het)arylisoxazoles with complementary regioselectivity

Efficient routes for the regioselective synthesis of 3,5-bis(het) arylisoxazoles with complementary regioselectivity have been developed. The methods involve the cyclocondensation of hydroxylamine hydrochloride with either 1,3-bis(het)aryl-monothio-substituted 1,3-diketones 1 or with 3-methylthio-1,3-bis(het)aryl-2-propenones 2 under various reaction conditions. In the first protocol, diketones 1 were treated with hydroxylamine hydrochloride in the presence of sodium acetate/acetic acid (pH 2.2) in refluxing ethanol/benzene to give 3,5-bis(het)arylisoxazoles 5, in which the het(aryl) moiety attached to thiocarbonyl group of the monothio-substituted 1,3-diketones is installed at the 3-position. On the other hand, the reaction of hydroxylamine hydrochloride with 3-(methylthio)-1,3-bis(het)aryl-2-propenones 2 in the presence of barium hydroxide in refluxing ethanol gave 3,5-bis(het) arylisoxazoles 6 with complementary regioselectivity in high yields. A probable mechanism for the formation of regioisomeric isoxazoles 5 and 6 from precursors 1 and 2 has been suggested.