454253-30-6

Basic information

• Product Name: trifluoromethanesulfonic acid 3-phenyl-isoxazol-5-yl ester
• Synonyms: trifluoromethanesulfonic acid 3-phenyl-isoxazol-5-yl ester
• CAS NO: 454253-30-6
• Molecular Weight: 293.223
• Mol File: 454253-30-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: trifluoromethanesulfonic acid 3-phenyl-isoxazol-5-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: trifluoromethanesulfonic acid 3-phenyl-isoxazol-5-yl ester(454253-30-6)
• EPA Substance Registry System: trifluoromethanesulfonic acid 3-phenyl-isoxazol-5-yl ester(454253-30-6)

Safety Data

• Hazardous Substances Data: 454253-30-6(Hazardous Substances Data)

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 1076-59-1 3-phenyl-4H-isoxazol-5-one 

Downstream Products

• 5592-17-6 3-phenyl-5-ethenylisoxazole 
• 2976-13-8 5-(2′-furyl)-3-phenylisoxazole 
• 1148-87-4 5-(4-chlorophenyl)-3-phenylisoxazole 
• 77252-64-3 5-(4-fluorophenyl)-3-phenyl-isoxazole 
• 3672-51-3 5-(4-methoxyphenyl)-3-phenylisoxazole 
• 25856-11-5 5-(3-methoxy-phenyl)-3-phenyl-isoxazole 
• 79182-04-0 5-(4′-trifluoromethylphenyl)-3-phenylisoxazole 
• 1157-94-4 5-(naphthalene-2-yl)-3-phenylisoxazole 
• 2039-49-8 3,5-diphehylisoxazole 
• 6797-27-9 3-phenyl-5-(phenylethynyl)isoxazole 
• 10285-00-4 4-(3-phenylisoxazol-5-yl)morpholine 
• 94447-61-7 5-(benzyloxy)-3-phenylisoxazole 

Relevant articles and documents

General Platform for the Conversion of Isoxazol-5-ones to 3,5-Disubstituted Isoxazoles via Nucleophilic Substitutions and Palladium Catalyzed Cross-Coupling Strategies

A general platform for the conversion of isoxazol-5-ones to 3,5-disubstituted isoxazoles has been developed via a two-step strategy. The first step leads to the formation of 5-(pseudo)halogenated isoxazoles, while in the second, a variety of heteroalkyl-, heteroaryl-, alkyl-, alkenyl-, alkynyl- and aryl-chains can be installed via nucleophilic substitutions or palladium catalyzed cross-coupling reactions.

Sonogashira coupling of functionalized trifloyl oxazoles and thiazoles with terminal alkynes: Synthesis of disubstituted heterocycles

(Matrix presented) This paper describes Sonogashira cross-coupling of functionalized 2-, 4-, and 5-trifloyl oxazoles and thiazoles with terminal alkynes. This methodology has been extended to 2,4-ditrifloylthiazoles, which results in regioselective cross-coupling at the C2-position of the thiazole. The resulting 2-alkynyl-4-trifloylthiazoles are effective electrophiles in a second palladium(0)-mediated cross-coupling reaction.