115706-16-6Relevant academic research and scientific papers
Synthesis of Oxazine, Thiazine, and Quinoxaline Derivatives Containing a Benzyl Fragment from 3-Aryl-2-Bromopropanoic Acids and Their Esters
Martyak, R. L.,Matiychuk, V. S.,Obushak, M. D.,Pokhodylo, N. T.,Rogovyk, M. P.
, p. 532 - 539 (2021/06/01)
Abstract: 3-Aryl-2-bromopropanoic acid esters reacted with o-phenylenediamine, 2-sulfanylaniline, and L-cysteine to give quinoxaline, 1,4-thiazine, and thiomorpholine derivatives, respectively, containing an aryl-methyl substituent. Analogous 1,4-benzoxaz
Benzo-aza-alkyl aryl piperazine derivative and applications in preparation of drugs
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Paragraph 0089-0092, (2019/02/10)
The invention discloses a benzo-aza-alkyl aryl piperazine derivative and applications in preparation of drugs. The derivative shows the effect on central nervous systems, especially on the double highaffinity activity of a 5-HT acceptor and a Sigma-1 acceptor. Various physiological and pharmacological effects are brought into play in the body; and the compound can be used as a pharmaceuticalactive substance, especially used for anti-depression, anti-anxiety, anti-bipolar affective disorder and anti-neuropathic pain, and can also be used as an intermediate to prepare other pharmaceuticalactive compounds. The compound is fast in effect and small in toxic and side effect, and can meet demands of clinical applications; and the compound is a compound or a free base or salt thereof havingthe following structural formula (IV). The structure of the compound or the free base or salt thereof is shown as the structural formula (IV).
One-pot synthesis of alkyl 3-aryl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoates
Pokhodylo,Savka,Obushak
, p. 734 - 737 (2017/07/07)
Reaction of 3-aryl-2-bromopropanoic acids esters, products of the Meerwein arylation, with sodium azide afforded alkyl 2-azido-3-arylpropanoates. The latter react with ethyl acetoacetate and phenylacetylene to form 1,2,3-triazole derivatives. A one-pot me
Synthesis and Antileukemic Activity of Bismethyl>-Substituted Pyrroloisoquinolines, Pyrroloquinolines, Pyrroloisobenzazepines, and Pyrrolobenzazepines
Anderson, Wayne K.,Heider, Arvela R.,Raju, Natarajan,Yucht, Jeffery A.
, p. 2097 - 2102 (2007/10/02)
A series of bismethyl>-substituted pyrrole-fused tricyclic heterocycles were synthesized by using 1,3-dipolar cycloaddition reactions with a trifluoromethanesulfonate salt of an appropriate Resissert compound or with a mesoionic oxazolone intermediate.All of the bis(carbamates) were active in vivo against P388 lymphocytic leukemia with 5,6-dihydro-8-methoxy-1,2-bis(hydroxymethyl)pyrroloisoquinoline bis (3c) showing the highest level of activity.
