115730-99-9Relevant academic research and scientific papers
Practical Synthesis of Some Versatile Chiral Building Blocks from (D)-Mannitol
Takano, Seiichi,Kurotaki, Ayako,Takahashi, Michiyasu,Ogasawara, Kunio
, p. 403 - 406 (1986)
The three chiral building blocks ethyl 4,5-O-isopropylidene-(E)-(S)-4,5-dihydroxy-2-pentenoate , (S)-5-hydroxy-4-pentanolide , and (S)-5-hydroxy-2-penten-4-olide are conveniently prepared from 1,2:5,6-di-O-isopropylidene-D-mannitol (4) via a glycol cleavage and Horner-Emmons reaction sequence.
