115791-87-2Relevant academic research and scientific papers
Copper-Catalyzed Decarboxylative Alkylation of Terminal Alkynes
Ye, Changqing,Li, Yajun,Bao, Hongli
, p. 3720 - 3724 (2017)
A copper-catalyzed decarboxylative alkylation of terminal alkynes under mild reaction conditions has been reported. Various alkyl diacyl peroxides were applied as the alkyl source for the formation of C(sp3)?C(sp) bond. A range of terminal alkynes including aryl alkynes and alkyl alkynes delivered the alkylated internal alkynes with good to high performances. Mechanism studies suggested that this reaction involves a free radical pathway. (Figure presented.).
Synthesis of Aryloxy Analogues of Arachidonic Acid via Wittig and Palladium Catalysed Cross-coupling Reactions
Buckle, Derek R.,Fenwick, Ashley E.,Outred, D. James,Rockell, Caroline J. M.
, p. 3144 - 3177 (2007/10/02)
The synthesis of o- and p-phenoxy analogues of arachidonic acid is described.In particular, the Wittig olefination reaction of hydroxy and alkyloxy benzaldehydes has been investigated and the products shown to be highly dependent on the solvent used.E/Z isomer control was difficult to achieve in most cases, although there was a tendency towards Z-isomer formation in dimethyl sulphoxide compared to tetrahydrofuran, particularly for the phenolic compounds.Specific Z-isomer formation was achieved by the partial reduction of alkynes derived from appropriately protected bromophenols via Heck or palladium catalysed cross-coupling reactions.
