1158-35-6

Basic information

• Product Name: H-D-Lys(Z)-OMe . HCl
• Synonyms: H-D-LYS(Z)-OME HCL
• CAS NO: 1158-35-6
• Molecular Formula: C₁₅H₂₂N₂O₄*ClH
• Molecular Weight: 330.81
• Mol File: 1158-35-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: H-D-Lys(Z)-OMe . HCl(CAS DataBase Reference)
• NIST Chemistry Reference: H-D-Lys(Z)-OMe . HCl(1158-35-6)
• EPA Substance Registry System: H-D-Lys(Z)-OMe . HCl(1158-35-6)

Safety Data

• Hazardous Substances Data: 1158-35-6(Hazardous Substances Data)

Usage

Uses

H-D-Lys(z)-ome Hydrochloride is a useful intermediate used in the preparation of analgesic dipeptide derivatives with analgesic properties.

Upstream product

• 67-56-1 methanol 
• 34404-32-5 (R)-2-amino-6-(((benzyloxy)carbonyl)amino)hexanoic acid 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 1437-00-9 Carbobenzoxy-D-valyl-ε-carbobenzoxy-D-lysin-methylester 
• 1437-02-1 Carbobenzoxy-D-valyl-ε-carbobenzoxy-L-lysin-methylester 
• 100103-10-4 Boc-Arg(NO₂)-D-Lys(Z)-OMe 
• 97485-07-9 N^α,N^ε-Bis(benzyloxycarbonyl)-D-lysyl-N^ε-(benzyloxycarbonyl)-D-lysine Methyl Ester 
• 328236-02-8 (R)-6-Benzyloxycarbonylamino-2-[(1-{4-[(3,5-dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-hexanoic acid methyl ester 

Relevant articles and documents

Discovery of SHR0687, a Highly Potent and Peripheral Nervous System-Restricted KOR Agonist

Analgesics with no abuse liability are highly demanded in the market. KOR agonists have been proved to be strong analgesics without MOR agonist-related side effects, such as respiratory depression, tolerance, and dependence liability; however, activation

PHENYL PROPANAMIDE DERIVATIVE, AND MANUFACTURING METHOD AND PHARMACEUTICAL APPLICATION THEREOF

The present invention provides a phenyl propanamide derivative as represented by formula (I), a manufacturing method of the derivative, application of the derivative as a κ-opioid receptor (KOR) agonist, and application of the derivative for manufacturing a pharmaceutical product for treating and/or preventing pain or a pain-related disease.