115802-03-4Relevant academic research and scientific papers
A Simple and Clean Synthesis of Polysubstituted 2,6-Dicyanoanilines Catalyzed by KF/alumina
Jain, Shubha,Keshwal, Balwant S.,Rajguru, Deepika,Bhagwat, Vasant W.
, p. 712 - 715 (2013/03/29)
A simple and clean synthesis of polysubstituted 2,6-dicyanoanilines has been developed via the reaction of arylidenemalonodinitriles with 1-arylethylidenemalonodinitriles in ethanol catalyzed by KF/ alumina. Use of non-hazardous solid base as a catalyst,
Synthesis and antiradiation activity of some sulfur containing thiophene derivatives
Hassan,Ghorab,Nassar
, p. 77 - 86 (2007/10/03)
Condensation of 2-(2,2-dicyano-1-methylvinyl)thiophene (2) with phenylhydrazine furnished the corresponding 2-(1-phenylhydrazonoethyl)-thiophene (4). Compound (4) was obtained also via reaction of (1) with phenylhydrazine. Reaction of (2) with amines gave 2-(2,2-dicyano-1-ethylamino or benzylamino-1 methylethyl)thiophene (5a,b). Treatment of (2) with elemental sulfur yielded directly the cyclised product 2-(5-amino-4-cyano-3-thienyl)thiophene (6). On the other hand refluxing (2) in pyridine with carbon disulfide gave the pyridine-1,3-dithione derivative (7). Condensation of (2) with phenyl isocyanate and/or phenyl isothiocyanate afforded 6-amino-4-(2-thienyl)-1,2-dihydro-2-oxo-1-phenylpyridine-5-carbonitrile (9) and/or 5-(2-thienyl)-2,7-dithioxo-3,8-N-phenyl-1,2,3,7,8-pentahydropyrido[2,3-d] pyrimidine-4-imine (11). Also the dicyano derivative (2) when reacted with cinnamonitrile (12) afforded the 2-(3-amino-2,4-dicyano-5-arylphenyl)-thiophenes (15a-d). Conversion of (15b) into the polyazanaphthalene (17) and (18) was affected via cyclocondensation with phenyl isocyanate and/or phenyl isothiocyanate. Compound (15a) showed promising antiradiation activity.
Nitriles in Organic Synthesis. The Chemical Behavior of - and malononitriles
El-Maghraby, Mohamed Abdallah,Sadek, Kamal Usef,Selim, Maghraby Ali,Elnagdi, Mohamed Hilmy
, p. 1375 - 1378 (2007/10/02)
The chemical behavior of - and malononitriles 1a and b toward electrophilic reagents, active methylene reagents and (arylmethylene)malononitriles is described.
Nitriles in Organic Synthesis: Synthesis of Polysubstituted Anilines and Cyclohexenones
Elagamey, Abdel-Ghani Ali
, p. 766 - 768 (2007/10/02)
Crotononitriles (I) react with cinnamonitriles (III) to afford anilines (IV), ylidenes (VI) or cyclohexenones (VIII).The nature of the end products in these reactions depends on the nature of the reactants and the reaction conditions.
