115858-97-4

Basic information

• Product Name: 4-Pyridinepropanenitrile, a-(4-fluorophenyl)-b-oxo-
• CAS NO: 115858-97-4
• Molecular Formula: C14H9FN2O
• Molecular Weight: 240.237
• Mol File: 115858-97-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-Pyridinepropanenitrile, a-(4-fluorophenyl)-b-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinepropanenitrile, a-(4-fluorophenyl)-b-oxo-(115858-97-4)
• EPA Substance Registry System: 4-Pyridinepropanenitrile, a-(4-fluorophenyl)-b-oxo-(115858-97-4)

Safety Data

• Hazardous Substances Data: 115858-97-4(Hazardous Substances Data)

Upstream product

• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 459-22-3 4-fluorophenylacetonitrile 
• 1570-45-2 isonicotinic acid ethylester 

Downstream Products

• 1075193-57-5 3-(4-fluorophenyl)-1-methoxymethoxy-2-pyridin-4-yl-1H-pyrrolo[3,2-b]pyridine 
• 1075193-43-9 3-(4-fluorophenyl)-1-methoxymethyl-6-methyl-2-pyridin-4-yl-1H-pyrrolo[3,2-b]pyridine 
• 1075193-38-2 3-(4-fluorophenyl)-6-methyl-2-pyridin-4-yl-1H-pyrrolo[3,2-b]pyridine 
• 1075197-80-6 (2-chloro-5-methylpyridin-3-yl)-[2-(4-fluorophenyl)-1-pyridin-4-ylethylidene]amine 
• 148611-82-9 5-amino-4-(4-fluorophenyl)-3-(pyridin-4-yl)pyrazole 
• 115858-99-6 1-(4-pyridyl)-2-(4-fluorophenyl)-1-<(tolylsulfonyl)imino>ethane 
• 115859-00-2 1-(4-pyridyl)-1-ethoxy-2-(4-fluorophenyl)aziridine 
• 72882-75-8 4-(4-fluorophenyl)-5-(pyridin-4-yl)-1,3-dihydro-imidazole-2-thione 
• 115859-01-3 1-(4-pyridyl)-2-(4-fluorophenyl)ethanone oxime 
• 610270-92-3 2-(2-chloropyridin-4-yl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine 

Relevant articles and documents

Targeting the ribose and phosphate binding site of p38 mitogen-activated protein (MAP) kinase: Synthesis and biological testing of 2-alkylsulfanyl-, 4(5)-aryl-, 5(4)-heteroaryl-substituted imidazoles

Three series of substituted 2-alkylsulfanyl-4-(4-fluorophenyl)imidazoles, 5-pyridinyl-, 1-methyl-5-pyridinyl-, and 5-(2-aminopyridin-4-yl)-imidazoles, were prepared and tested for their ability to inhibit p38 MAP kinase and TNF-α release. These compounds

Design and Synthesis of 4-Azaindoles as Inhibitors of p38 MAP Kinase

Inhibition of the biosynthesis of proinflammatory cytokines such as tumor necrosis factor and interleukin-1 via p38 has been an approach toward the development of a disease modifying agent for the treatment of chronic inflammation and autoimmune diseases.

Synthetic and Mechanistic Studies on the Preparation of Pyridyl-Substituted Imidazothiazoles

A new method is presented for the introduction of the 4'-pyridyl substituent into 6-aryl-2,3-dihydroimidazothiazoles.The method involves treatment of the imidazothiazolines with the reactive complex of pyridine and ethyl chloroformate and oxidative deethyl carboxylation of the dihydropyridine adducts formed.Sulfur in refluxing mesitylene was found most suitable for the latter reaction, but chromium trioxide in pyridine or KtBuO and air were also effective.