115891-29-7

Upstream product

• 371-40-4 4-fluoroaniline 
• 446-26-4 methyl 2-fluoro-3-pyridinecarboxylate 
• 57978-51-5 2-((4-fluorophenyl)amino)nicotinic acid 
• 2942-59-8 2-chloronicotinic acid 

Downstream Products

• 57978-51-5 2-((4-fluorophenyl)amino)nicotinic acid 
• 115891-98-0 Acetic acid 3-butyl-1-(4-fluoro-phenyl)-2-oxo-1,2-dihydro-[1,8]naphthyridin-4-yl ester 
• 115891-97-9 3-Butyl-1-(4-fluoro-phenyl)-4-hydroxy-1H-[1,8]naphthyridin-2-one 
• 115891-52-6 2-[(4-Fluoro-phenyl)-hexanoyl-amino]-nicotinic acid methyl ester 

Relevant academic research and scientific papers

TRPA1 MODULATORS

Compounds of formula la or lb, wherein R1 and R2 are as defined in the claims, exhibit TRPA1 activity and are thus useful as TRPA1 modulators.

Antiallergy Agents. 1. Substituted 1,8-Naphthyridin-2(1H)-ones as Inhibitors of SRS-A Release

A novel class of antiallergy agents, the substituted 1,8-naphthyridin-2(1H)-ones, is described.The present compounds are orally active, potent inhibitors of allergic and nonallergic bronchospasm in animal models.Structure-activity studies of the lead compound in this sereis, 1-phenyl-3-n-butyl-4-hydroxynaphthyridin-2(1H)-one (11), identified three compounds of interest, 1-phenyl-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one (12), 1-(3'-chlorophenyl)-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one (87), and 1-(3'-methoxyphenyl)-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one (89).The mechanism of antiallergy activity may involve inhibition of the release of the sulfidopeptide leukotrienes. 1-Phenyl-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one, Sch 33303 (12), was selected for preclinical development as an antiallergy agent.