115913-83-2 Usage
Chemical Class
Pyrimidine nucleosides
Explanation
The compound belongs to a class of chemical compounds known as pyrimidine nucleosides, which are derivatives of the base pyrimidine.
Explanation
It is used as an antiviral medication, particularly for the treatment of HIV and Hepatitis B.
Explanation
The compound works by inhibiting the reverse transcriptase enzyme, which is essential for the replication of the viruses.
Explanation
It has shown promising results in reducing the viral load in patients with HIV and Hepatitis B.
Explanation
The compound helps in slowing down the progression of HIV and Hepatitis B by inhibiting the replication of the viruses.
Explanation
The compound is still under investigation for potential use in other antiviral therapies.
Explanation
The compound has a specific chemical structure, which includes a 5-methylpyrimidine base attached to a modified sugar moiety (3-cyano-3-deoxy-beta-D-arabinofuranosyl).
Explanation
The compound is a synthetic nucleoside analog, meaning it is a modified version of a naturally occurring nucleoside with antiviral properties.
Application
Antiviral medication
Mechanism of Action
Inhibition of reverse transcriptase enzyme
Effect on Viral Load
Reduction
Impact on Disease Progression
Slowing down
Current Status
Under investigation
Structure
1-(3-cyano-3-deoxy-beta-D-arabinofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
Synthetic Analog
Yes
Check Digit Verification of cas no
The CAS Registry Mumber 115913-83-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,9,1 and 3 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 115913-83:
(8*1)+(7*1)+(6*5)+(5*9)+(4*1)+(3*3)+(2*8)+(1*3)=122
122 % 10 = 2
So 115913-83-2 is a valid CAS Registry Number.
115913-83-2Relevant academic research and scientific papers
Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides
Herdewijn,Balzarini,Baba,Pauwels,Van Aerschot,Janssen,De Clerq
, p. 2040 - 2048 (2007/10/02)
A series of base-modified pyrimidine 3'-azido-2',3'-dideoxynucleosides and 3'-substituted purine and pyrimidine 2',3'-dideoxynucleosides have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV) replication in MT-4 cells. The following pyrimidine derivatives emerged as the most potent and/or selective inhibitors of HIV-induced cytopathogenicity (in order of decreasing selectivity: 3'-azido-3'-deoxythymidine (AZT), 3'-azido-2',3'-dideoxyuridine (AzddUrd), 3'-azido-2',3'-dideoxy-5-methylcytidine (AzddMeCyd), 3'-fluoro-ddUrd (FddUrd), 3'-fluoro-ddThd (FddThd), the N4-hydroxylated derivative of AzddMeCyd and the N4-methylated derivative of AzddMeCyd. Among the purine 2',3'-dideoxynucleosides, 3'-azido-2',3'-dideoxyguanosine (AzddGuo), 3'-fluoro-ddGuo (FddGuo), and 3'-fluoro-2,6-diaminopurine 2',3'-dideoxynucleoside (FddDAPR) were the most selective inhibitors of HIV replication.
SYNTHESIS AND ANTI-HIV ACTIVITY OF 3'-CYANO-2',3'-DIDEOXYTHYMIDINE AND 3'-CYANO-2',3'-DIDEHYDRO-2',3'-DIDEOXYTHYMIDINE
Matsuda, Akira,Satoh, Mutsumi,Nakashima, Hideki,Yamamoto, Naoki,Ueda, Tohru
, p. 2545 - 2548 (2007/10/02)
3'-Cyano-2',3'-dideoxy- and 3'-cyano-2',3'-didehydro-2',3'-dideoxythymidines (4,5) have been synthesized from 5-methyluridine (7).Anti-HIV activity of these compounds is also described.
