115919-87-4Relevant academic research and scientific papers
Identification of thienopyridine carboxamides as selective binders of HIV-1: Trans Activation Response (TAR) and Rev Response Element (RRE) RNAs
Li, Xue-Dong,Liu, Li,Cheng, Liang
supporting information, p. 9191 - 9196 (2019/01/03)
Small organic molecules that can selectively bind to RNA with specificity are relatively rare. Here we report the synthesis, biochemical and structural studies of thienopyridine carboxamide derivatives with the capacity of selectively recognizing and binding with HIV-1 TAR and RRE RNAs that are essential elements for viral replication.
Discovery and structure-activity relationships study of novel thieno[2,3-b]pyridine analogues as hepatitis C virus inhibitors
Wang, Ning-Yu,Zuo, Wei-Qiong,Xu, Ying,Gao, Chao,Zeng, Xiu-Xiu,Zhang, Li-Dan,You, Xin-Yu,Peng, Cui-Ting,Shen, Yang,Yang, Sheng-Yong,Wei, Yu-Quan,Yu, Luo-Ting
, p. 1581 - 1588 (2014/03/21)
Current treatment for hepatitis C is barely satisfactory, there is an urgent need to develop novel agents for combating hepatitis C virus infection. This study discovered a new class of thieno[2,3-b]pyridine derivatives as HCV inhibitors. First, a hit compound characterized by a thienopyridine core was identified in a cell-based screening of our privileged small molecule library. And then, structure activity relationship study of the hit compound led to the discovery of several potent compounds without obvious cytotoxicity in vitro (12c, EC50 = 3.3 μM, SI >30.3, 12b, EC50 = 3.5 μM, SI >28.6, 10l, EC50 = 3.9 μM, SI >25.6, 12o, EC 50 = 4.5 μM, SI >22.2, respectively). Although the mechanism of them had not been clearly elucidated, our preliminary optimization of this class of compounds had provided us a start point to develop new anti-HCV agents.
Synthesis and characterization of 6-(aryl)-2-thioxo-1,2-dihydropyridine-3- carbonitriles
Attaby, Fawzy A.,El-Ghandour, Ahmed H.,Sayed, Abdelwahed R.,El Bassuony, Ashraf A.,El-Reedy, Ahmed A.M.
scheme or table, p. 197 - 221 (2012/06/01)
In the present study, 3-aminothieno[2,3-b]pyridines, pyrido[3′, 2′:4,5]thieno[3,2-d]pyrimidinones, and pyrido[3′,2′:4,5] thieno[3,2-d][1,3]oxazinones were prepared via the reaction of 6-(aryl)-2-thioxo-1,2-dihydropyridine-3-carbonitriles with active-halog
Surprising reaction of 3-(2-chloro-ethyl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidinones with α,ω-diamino-alkanes to tetracyclic compounds with an anellated dihydroimidazo-, dihydropyrimido- or tetrahydro-1,3-diazepino-ring
Vieweg,Leistner,Bohm,Prantz,Wagner
, p. 26 - 30 (2007/10/02)
Bis- and monoacylated compounds of structure B reacted with ω-hydroxyalkylamines to give the tricyclic 3-(ω-hydroxy-alkyl)pyrido[3',2':4,5]thieno[3,2-d] pyrimidin-4-(3 H)-ones. The title compounds were obtained by the reaction of the 3-(2-chloroethyl) der
