41125-10-4Relevant academic research and scientific papers
A Method for the Preparation of β-Amino-α,β-unsaturated Carbonyl Compounds: Study of Solvent Effect and Mechanism
R. S., Reyno,Sugunan, Akash,S., Ranganayakulu,Suresh, Cherumuttathu H.,Rajendar, Goreti
supporting information, p. 1040 - 1045 (2020/02/15)
An efficient method for the preparation of β-amino-α,β-unsaturated carbonyl compounds is demonstrated. Bench-stable sodium 3-oxo-enolates were prepared from carbonyl compounds, and reacted with amines in the presence of an acid and a desiccant. DFT studie
Thiophosphoryl-Functionalized enaminoketones: Synthesis, structure, and complexing properties towards transition metal ions
Aleksanyan, Diana V.,Aleksenko, Valentina Yu.,Nelyubina, Yulia V.,Klemenkova, Zinaida S.,Kozlov, Vladimir A.
, p. 183 - 190 (2014/01/17)
P(X)-functionalized enaminoketones (X = O, S) 1a,b have been readily obtained by the condensation of o-(thio)phosphorylated anilines with sodium salt of benzoylacetaldehyde. The ligands derived exist in solution in the expected ketamino tautomeric form, b
Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives
Liu, Jinbing,Cao, Rihui,Wu, Qifeng,Ma, Chunming,Wang, Zihou,Peng, Wenlie,Song, Huacan
experimental part, p. 1737 - 1744 (2009/05/30)
A series of novel 4-alkylphenyl β-aldehyde ketones and their derivatives were designed and synthesized on the basis of the chemical structures of Houttuynin and β-lactam antibiotics. Antibacterial activities of these compounds were investigated. The results demonstrated that most of the compounds tested had moderate antibacterial activities against Gram-positive pathogen Staphylococcus aureus (ATTC-25923) than Houttuynin, and Gram-positive bacteria were more susceptible to the compounds than Gram-negative bacteria. Compound 23 was found to be the most potent compound with MIC of 1.0 μg/mL against S. aureus. Particularly, compounds 16, 22 and 23 showed more active antibacterial activities against the clinically important pathogenic bacteria, methicillin-resistant S. aureus (MRSA) than Houttuynin and levofloxacin. The preliminary structure-activity relationship (SAR) analysis suggested that (1) the introduction of appropriate alkyl substituents into position 4 of phenyl ring enhanced antibacterial activities of these compounds, and isopropyl substituent might be more favorable; (2) the presence of ketone carbonyl moiety might play a vital role in determining significant antibacterial activities of these compounds.
PROCESS FOR PRODUCING 3-SUBSTITUTED THIOPHENE
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Page/Page column 27, (2008/06/13)
A process for producing a 3-substituted thiophene represented by the general formula (2): (wherein R represents cyano, formyl, carboxy, optionally substituted hydrocarbyloxycarbonyl, or optionally substituted acyl), characterized by reacting a vinyl compound represented by the general formula (1): RCH=CHY (wherein R has the same meaning as defined above; and Y is a leaving group) with α-mercaptoacetaldehyde or a polymer thereof.
