118188-69-5

Upstream product

• 25442-44-8 1-(3'-iodo-2',3'-dideoxy-5'-O-trityl-β-D-erythro-pentofuranosyl)thymine 
• 50-89-5 thymidine 
• 76-83-5 trityl chloride 
• 121336-20-7 (2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-2,5-dihydro-furan-3-carbonitrile 
• 115941-56-5 1-(3-cyano-3-deoxy-5-O-trityl-β-D-arabinofuranosyl)thymine 
• 115913-84-3 1-(2,3-epoxy-5-O-trityl-β-D-lyxo-pentofuranosyl)thymine 
• 7791-71-1 5'-O-tritylthymidine 
• 121336-21-8 1-(3'-cyano-2',3'-dideoxy-5'-O-trityl-β-D-threo-pentofuranosyl)thymine 
• 119072-55-8 tert-butylisonitrile 

Downstream Products

• 116195-58-5 1-(3'-C-cyano-2',3'-dideoxy-β-D-erythro-pentofuranosyl)thymine 
• 140659-84-3 3'-deoxy-3'-C-formyl-5'-O-tritylthymidine 
• 497068-94-7 3'-deoxy-3'-(1H-terazol-5-yl)-5'-O-tritylthymidine 
• 140659-91-2 C₅₇H₆₃N₅O₉Si 
• 161277-51-6 C₅₆H₅₉N₅O₉Si 
• 140659-93-4 C₄₃H₄₉N₅O₁₁ 
• 140676-15-9 C₅₆H₆₁N₅O₉Si 
• 183064-10-0 Acetic acid (2S,3R,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-ylmethyl ester 
• 146604-41-3 1-((2R,4R,5S)-4-Hydroxymethyl-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 164007-66-3 5'-O-Dimethoxytrityl-3'-acetoxymethyl-3'-deoxy-thymidine 
• 164007-67-4 5'-O-dimethoxytrityl-3'-hydroxymethyl-3'-deoxy-thymidine 
• 497069-01-9 3'-deoxy-3'-[2-(5'-deoxythymidin-5'-yl)-2H-tetrazol-5-yl]-5'-O-(4,4'-dimethoxytrityl)thymidine 
• 497068-98-1 3'-deoxy-3'-[2-(5'-deoxythymidin-5'-yl)-2H-tetrazol-5-yl]-5'-O-tritylthymidine 

Relevant academic research and scientific papers

Synthesis of 5'-phosphonate linked thymidine deoxyoligonucleotides

5'-Deoxy-5'-phosphonothymidine was synthesized and coupled with 3'-deoxy-3'-hydroxy-methylthymidine to yield a 3'-C-O-P-5' linked thymidine dinucleotide. This dimer as its 3'-phosphoramidite was used to synthesize deoxyoligonucleotides.

SYNTHESIS AND ANTI-HIV ACTIVITY OF 3'-CYANO-2',3'-DIDEOXYTHYMIDINE AND 3'-CYANO-2',3'-DIDEHYDRO-2',3'-DIDEOXYTHYMIDINE

3'-Cyano-2',3'-dideoxy- and 3'-cyano-2',3'-didehydro-2',3'-dideoxythymidines (4,5) have been synthesized from 5-methyluridine (7).Anti-HIV activity of these compounds is also described.