115975-32-1Relevant academic research and scientific papers
Rapid and Direct Photocatalytic C(sp3)?H Acylation and Arylation in Flow
Bovy, Lo?c,Broersma, Rémy,Mazzarella, Daniele,No?l, Timothy,Pulcinella, Antonio
supporting information, p. 21277 - 21282 (2021/08/23)
Herein, we report a photocatalytic procedure that enables the acylation/arylation of unfunctionalized alkyl derivatives in flow. The method exploits the ability of the decatungstate anion to act as a hydrogen atom abstractor and produce nucleophilic carbon-centered radicals that are intercepted by a nickel catalyst to ultimately forge C(sp3)?C(sp2) bonds. Owing to the intensified conditions in flow, the reaction time can be reduced from 12–48 hours to only 5–15 minutes. Finally, kinetic measurements highlight how the intensified conditions do not change the reaction mechanism but reliably speed up the overall process.
ACTIVATION OF CARBOXYLIC ACIDS AND ALCOHOLS BY INTRAMOLECULAR CYCLIZATION. ACYLATION OF TRIMETHYLSYSLILACETYLENES AND ALKYLATION OF AROMATIC COMPOUNDS
Fukuoka, Satoshi,Nanri, Hiroshi,Katsuki, Tsutomu,Yamaguchi, Masaru
, p. 6205 - 6206 (2007/10/02)
Carboxylic α-bromo-o-toluic anhydrides and alkyl α-bromo-toluates were activated by silver salts and used for the acylation of trimethylsilylacetylenes to acetylenic ketones and alkylation of aromatic compounds, respectively.
