116016-65-0

Upstream product

• 14300-29-9 3-Methyl-2-phenylthiophene 
• 116016-64-9 2-bromo-3-methyl-5-phenylthiophene 
• 1402143-75-2 methyl 2-bromo-5-phenylthiophene-3-carboxylate 
• 61325-02-8 2-amino-5-phenylthiophene-3-carboxylic acid methyl ester 
• 38695-72-6 methyl 5-phenylthiophene-3-carboxylate 
• 122-78-1 phenylacetaldehyde 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 116016-62-7 5-(1-methylcinnamylidene)rhodanine 
• 595565-66-5 (2Z,4E)-2-Mercapto-3-methyl-5-phenyl-penta-2,4-dienoic acid 
• 23806-25-9 3-methyl-5-phenylthiophene-2-carboxylic acid 

Downstream Products

• 1402143-77-4 2-(2-bromo-5-phenylthiophen-3-yl)-2-[(trimethylsilyl)oxy]acetonitrile 
• 1402143-79-6 methyl 2-(2-bromo-5-phenylthiophen-3-yl)-2-(tert-butoxy)acetate 
• 1402143-80-9 methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetate 
• 1402143-74-1 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetic acid 
• 1402143-78-5 methyl 2-(2-bromo-5-phenylthiophen-3-yl)-2-hydroxyacetate 
• 116016-68-3 5-<3-(2-bromo-5-phenyl-3-thienyl)acrylidene>rhodanine 
• 116016-69-4 (2Z,4E)-5-(2-Bromo-5-phenyl-thiophen-3-yl)-2-mercapto-penta-2,4-dienoic acid 
• 116016-67-2 3-(2-bromo-5-phenyl-3-thienyl)acrolein 
• 116016-66-1 3-(2-bromo-5-phenyl-3-thienyl)acrylic acid 

Relevant academic research and scientific papers

INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES

The present invention relates to compounds of formula (1) as claimed in claim 1, their use in the treatment or the prevention of viral disorders, including HIV. (Formula I)

Synthesis of Unsymmetrical Arylthiophenes and Bithienyls via Oxidative Cyclization of 1,3-Butadiene-1-thiols

Oxidative cyclization of 2-mercapto-5-aryl-2,4-pentanedienoic acids with iodine produced the respective 5-aryl-2-thenoic acids.The method was also suitable for the synthesis of unsymmetrical substituted 2,2,-bithienyls, and 2,3'-bithienyls.The synthesis o