1160221-76-0Relevant academic research and scientific papers
Total synthesis of brevenal
Zhang, Yuan,Rohanna, John,Zhou, Jie,Iyer, Karthik,Rainier, Jon D.
supporting information; experimental part, p. 3208 - 3216 (2011/04/25)
This Article describes the total synthesis of the marine ladder toxin brevenal utilizing a convergent synthetic strategy. Critical to the success of this work was the use of olefinic-ester cyclization reactions and the utilization of glycal epoxides as precursors to C-C and C-H bonds.
Total synthesis of brevenal
Takamura, Hiroyoshi,Yamagami, Yuji,Kishi, Takayuki,Kikuchi, Shigetoshi,Nakamura, Yuichi,Kadota, Isao,Yamamoto, Yoshinori
experimental part, p. 5329 - 5344 (2010/08/07)
The convergent total synthesis of brevenal, a non-toxic brevetoxin antagonist, has been achieved.The ABC ring segment and the E ring precursor were connected by the intramolecular allylation followed by ring-closing metathesis to furnish the pentacyclic e
Total synthesis of brevenal
Takamura, Hiroyoshi,Kikuchi, Shigetoshi,Nakamura, Yuichi,Yamagami, Yuji,Kishi, Takayuki,Kadota, Isao,Yamamoto, Yoshinori
supporting information; experimental part, p. 2531 - 2534 (2009/10/10)
A total synthesis of brevenal is described. The pentacyclic ether core was constructed by the intramolecular allylation of α-acetoxy ether and subsequent ring - closing metathesis. Both of the diene side chains were introduced by Wittig olefination and a
