1160246-91-2

Basic information

• Product Name: tert-butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
• Synonyms: tert-butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate;1-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 3-aMino-, 1,1-diMethylethyl ester;8-Boc-3-aMino-1-oxa-8-azaspiro[4.5]decane;3-Amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylic acid tert-butyl ester
• CAS NO: 1160246-91-2
• Molecular Formula: C13H24N2O3
• Molecular Weight: 256
• Mol File: 1160246-91-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 364.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.12
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.77±0.20(Predicted)
• CAS DataBase Reference: tert-butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate(1160246-91-2)
• EPA Substance Registry System: tert-butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate(1160246-91-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1160246-91-2(Hazardous Substances Data)

Usage

General Description

Tert-butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate, also known as TBOA-8, is a chemical compound with a unique spirocyclic structure. It is a derivative of the amino acid glycine and has been studied for its potential pharmacological properties, particularly in the context of its ability to modulate the activity of various neurotransmitter transport proteins. TBOA-8 has been investigated for its potential as a competitive antagonist of glutamate transporters, which play a critical role in regulating the levels of the neurotransmitter glutamate in the brain. Its unique structure and potential pharmacological activity make it a topic of interest for further research and potential therapeutic applications in the future.

Upstream product

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Relevant articles and documents

Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1-Oxa-8-azaspiro[4.5]decan-3-amine

Spirocyclic ring systems are useful intermediates in the design and synthesis of medicinally active agents and commonly found as cores in natural products. Recently, syntheses of a key intermediate Boc-protected-1-oxa-8-azaspiro[4.5]decan-3-amine 1 were examined. While multigram quantities of the racemic material could be made from the reduction of an energic azide intermediate, larger scale reactions and a chiral synthesis required further investigations. Herein, we describe the use of a continuous three-step flow process to scale the formation and reduction of an azide intermediate, and the use of a transaminase to prepare the desired enantiomer in high yield and enantiomeric excess.

1,1,1-TRIFLUORO-3-HYDROXYPROPAN-2-YL CARBAMATE DERIVATIVES AS MAGL INHIBITORS

The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating MAGL-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, depression, anxiety, Alzheimer's disease, a metabolic disorder, stroke, or cancer.