1160359-87-4Relevant academic research and scientific papers
Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators
Qin, Jun,Dhondi, Pawan,Huang, Xianhai,Mandal, Mihirbaran,Zhao, Zhiqiang,Pissarnitski, Dmitri,Zhou, Wei,Aslanian, Robert,Zhu, Zhaoning,Greenlee, William,Clader, John,Zhang, Lili,Cohen-Williams, Mary,Jones, Nicholas,Hyde, Lynn,Palani, Anandan
scheme or table, p. 664 - 669 (2011/02/27)
We herein report the discovery of four series of fused 5,6-bicyclic heterocycles as γ-secretase modulators. Synthesis and SAR of these series are discussed. These compounds represent a new class of γ-secretase modulators that demonstrate moderate to good
GAMMA SECRETASE MODULATORS
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Page/Page column 175, (2009/07/17)
This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein R2 is a fused bicyclic ring of the formula (II). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).
GAMMA SECRETASE MODULATORS FOR THE TREATMENT OF ALZHEIMER ' S DISEASE
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Page/Page column 275, (2009/10/21)
This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula: Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I
