116173-72-9Relevant articles and documents
Reaction of N-Acyl-α-methoxyamines with Organozic Reagents. A Convenient Method for the Synthesis of Homoallylamines and β-Amino Esters.
Kise, Naoki,Yamazaki, Hiroki,Mabuchi, Toshirou,Shono, Tatsuya
, p. 1561 - 1564 (1994)
The reaction of N-acyl-α-methoxyamines with allyl-, propargyl-, and benzylzinc bromides and Reformatsky reagents proceeds in THF at room temperature.Homoallyl- and homopropargylamines and β-amino esters are synthesized in good yields.
Effect of catalytic alkali metal bromide on Hofmann-type rearrangement of imides
Moriyama, Katsuhiko,Ishida, Kazuma,Togo, Hideo
supporting information; experimental part, p. 8574 - 8576 (2012/09/07)
The Hofmann-type rearrangement of aromatic and aliphatic imides using KBr as the catalyst proceeded to provide aromatic and aliphatic amino acid derivatives. We have also developed a new synthetic route to gabapentin with this method.
NEW SYNTHESIS OF β-AMINO ACIDS BY NUCLEOPHILIC ADDITION OF ENOLATE ANIONS TO N-METHOXYCARBONYLIMINES GENERATED FROM α-METHOXY CARBAMATES.
Shono, Tatsuya,Kise, Naoki,Sanda, Fumio,Ohi, Satoru,Tsubata, Kenji
, p. 231 - 234 (2007/10/02)
The nucleophilic addition of enolate anions of alkyl acetates to N-methoxycarbonylimines generated from α-methoxy carbamates gave β-amino acid derivates (3) and enantioselective synthesis (72-90percentee) of 3 was achieved by using chiral 2-methyloxazolines instead of acetates.
