Reaction of N-Acyl-α-methoxyamines with Organozic Reagents. A Convenient Method for the Synthesis of Homoallylamines and β-Amino Esters.

Article abstract of DOI:10.1016/S0040-4039(00)76758-X

The reaction of N-acyl-α-methoxyamines with allyl-, propargyl-, and benzylzinc bromides and Reformatsky reagents proceeds in THF at room temperature.Homoallyl- and homopropargylamines and β-amino esters are synthesized in good yields.