116173-81-0Relevant articles and documents
Facile one-pot synthesis of 2-oxazoline
Zhu, Jipeng,Zhou, Min,Jiang, Weinan,Zhou, Yang,Song, Gonghua,Liu, Runhui
supporting information, (2022/01/28)
We developed a facile one-pot synthesis of 2-oxazolines from carboxylic acid and 2-chloroethyl isocyanate, involving amide bond formation and a following intramolecular cyclization using 4-dimethylaminopyridine as the catalyst. A large variety of functional groups are well tolerated by the mild reaction conditions to afford diverse 2-oxazolines in good to excellent yields. This reaction will keep the chirality of the isocyanate at position 1, the R2 substituted carbon. Microwave-assisted synthesis can further enhance the reaction yield and reduce the reaction time to 5 min. This method facilities the synthesis of 2-oxazolines for diverse applications, such as 2-oxazoline derived polymers and materials.
SYNTHESIS OF OXAZOLINE COMPOUNDS
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Page/Page column 12, (2010/04/03)
The present invention provides an improved process for preparing an oxazoline compound of the formula: (I) wherein R1 and R2 are independently hydrogen, sulfide, sulfoxide, sulfonyl, optionally substituted lower alkyl, optionally sub
Asymmetric amidoselenenylation of alkenes promoted by camphorselenenyl sulfate: A useful synthetic route to enantiopure oxazolines
Tiecco, Marcello,Testaferri, Lorenzo,Santi, Claudio,Tomassini, Cristina,Marini, Francesca,Bagnoli, Luana,Temperini, Andrea
, p. 3451 - 3457 (2007/10/03)
Camphorselenenyl sulfate is an efficient chiral, nonracemic electrophilic reagent which can be produced from the easily available camphor diselenide by treatment with ammonium persulfate. This electrophilic selenium reagent reacts with alkenes, at room temperature in acetonitrile, in the presence of water and trifluoromethanesulfonic acid to afford the amidoselenenylation products with moderate facial selectivity. However, the two diastereomeric addition products can be easily separated. After activation of the selenium moiety with phenylselenenyl triflate or with SO2Cl2, these products are deselenenylated stereospecifically by intramolecular substitution and afford enantiomerically pure oxazolines.