1161744-07-5Relevant academic research and scientific papers
Improved method for synthetizing lamotrigine
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Paragraph 0036, (2018/07/06)
The invention discloses an improved method for synthetizing lamotrigine. The method comprises the following steps: step I, carrying out helogenating reaction through 3-amino-1,2,4-triazine (I) and a halogenating reagent in the presence of an organic solvent to obtain 3-amino 6-halogeno-1,2,4-triazine (II); step II, carrying out amination reaction of a compound II to prepare 3,5-diamino 6-halogeno-1,2,4-triazine (compound III); and step III, carrying out suzuki coupling reaction through the compound III and 2,3-dichlorobenzene boric acid derivative in the solvent under catalysis of palladium/[N,N] pyridine amidino ligand/alkali to prepare lamotrigine (IV). Through the method, metal cyanide is not used; meanwhile, the method is high in reaction selectivity and high in reaction yield.
Vinyl polymerization of norbornene catalyzed by 2-Py-amidine Ni(II) complex/methylaluminoxane systems
Niu, Yong-Ping,Wang, Xiao-Wei,Zheng, Zhi-Wu,Ma, Xiao-Fei,Cai, Jun-Qing,Zhang, Jun-Kai,Cheng, Jin-Lian
, p. 688 - 695 (2014/11/27)
Two 2-Py-amidine ligands (2-Py-NH-C(Ph) N-Ar, Ar = 2,6-Me2C 6H3 and 2,6-iPr2C6H 3) and the corresponding Ni(II) complexes (1 and 2) were synthesized and characterized using eleme
